Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-PE-A5DE-01A-11R-A27Q-07

· D

10bdb344-ee03-5ae3-9d04-435925745108

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
88
os_event
false

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-D8-A73U-01A-11R-A33J-07
breast-umap@18
D0.894
2SRR6013477
lung-landscapes@6
cohortMD20.892
3SRR8613709
breast-umap@18
A0.880
4TCGA-A2-A0CR-01A-11R-A22K-07
breast-umap@18
B0.868
5SRR2779183
melanoma-umap@29
0.867
6AUR-AD9F-TTM2-A-1-1-R-A542-39
breast-umap@18
D0.859
7TCGA-BH-A0B6-01A-11R-A19W-07
breast-umap@18
D0.857
8TCGA-AC-A2FE-01A-11R-A19W-07
breast-umap@18
A0.853
9BS_699TN5RN
brain-umap@2
Ganglioglioma0.852
10TCGA-LD-A9QF-01A-32R-A41B-07
breast-umap@18
D0.852

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_GAMMA_RESPONSE0.600Idelalisib— uncovered
ALLOGRAFT_REJECTION0.580Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.550Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.520Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.460Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.420Idelalisib— uncovered
KRAS_SIGNALING_UP0.360Inavolisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
IL2_STAT5_SIGNALING0.310Idelalisib— uncovered
APOPTOSIS0.300Idelalisib— uncovered
HEDGEHOG_SIGNALING0.300Inavolisib— uncovered
P53_PATHWAY0.270Idelalisib— uncovered
COAGULATION0.250Binimetinib— uncovered
PANCREAS_BETA_CELLS0.230Cobimetinib— uncovered
KRAS_SIGNALING_DN0.160Remibrutinib— uncovered
APICAL_SURFACE0.150Temsirolimus— uncovered
PI3K_AKT_MTOR_SIGNALING0.140Inavolisib— uncovered
UV_RESPONSE_UP0.140Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.130Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.120Inavolisib— uncovered