BS_052PZFMK
high-grade glioma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- high-grade glioma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- high-grade glioma
- age_years
- 18.548
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_G23JJAZY | EPN | Supratentorial EPN | 0.934 |
| 2 | SRR12202462 | — | — | 0.930 |
| 3 | MNG1063 | — | — | 0.927 |
| 4 | MBCproject_0227_T2_RNA | — | B | 0.924 |
| 5 | AUR-AFR3-TTM1-A-1-1-R-A743-41 | — | C | 0.919 |
| 6 | MDT-AP-2956 | Med | Medulloblastoma | 0.918 |
| 7 | BS_MV6ASWV9 | ATRT | — | 0.917 |
| 8 | BS_G23JJAZY | Supratentorial Ependymoma | — | 0.910 |
| 9 | TCGA-OR-A5LE-01 | Adrenocortical Carcinoma | Adrenocortical Carcinoma, Usual Type | 0.908 |
| 10 | BS_YBJBSRHV | Embryonal tumors | — | 0.907 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 22 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.610 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.576 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.552 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.466 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.465 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.366 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.343 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.300 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.298 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.272 | Remibrutinib | — uncovered |
| PEROXISOME | 0.248 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.184 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.162 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.137 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.112 | Cobimetinib | — uncovered |
| ANDROGEN_RESPONSE | 0.103 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.084 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.066 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.061 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.059 | Inavolisib | — uncovered |