Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · lung-landscapes@6

C3N-01020

— · cohortSQ1

134caccd-85df-5658-8e11-b75eead20d7d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
cohortSQ1
subtype
cohortSQ1
age_years
65.27310062

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8613750
breast-umap@18
—D0.814
2SRR8613788
breast-umap@18
—D0.813
3TCGA-BT-A42E-01A-11R-A23W-07
bladder-landscape@3
——0.813
4TCGA-OL-A66I-01A-21R-A29R-07
breast-umap@18
—D0.809
5BSR_05_0113_A2_S101
breast-umap@18
—D0.806
6MBCProject_7544_T1_RNA
breast-umap@18
—D0.804
7MNG1010
mng-umap@100
——0.803
8R50
bladder-landscape@3
——0.797
9SRR8518357
breast-umap@18
—D0.793
10TCGA-A2-A04Q-01A-21R-A034-07
breast-umap@18
—D0.793

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.490Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.460Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.450Inavolisib— uncovered
MYC_TARGETS_V20.450Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.430Idelalisib— uncovered
ALLOGRAFT_REJECTION0.410Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.410Inavolisib— uncovered
ANGIOGENESIS0.360Remibrutinib— uncovered
APICAL_SURFACE0.290Temsirolimus— uncovered
COMPLEMENT0.230Inavolisib— uncovered
E2F_TARGETS0.230Inavolisib— uncovered
G2M_CHECKPOINT0.230Inavolisib— uncovered
APICAL_JUNCTION0.170Inavolisib— uncovered
IL2_STAT5_SIGNALING0.170Idelalisib— uncovered
PANCREAS_BETA_CELLS0.170Cobimetinib— uncovered
KRAS_SIGNALING_DN0.140Remibrutinib— uncovered
MYC_TARGETS_V10.130Inavolisib— uncovered
SPERMATOGENESIS0.130Inavolisib— uncovered
UV_RESPONSE_UP0.130Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.100Inavolisib— uncovered