MNG44
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.259
- KRAS_SIGNALING_DN+0.243
- SPERMATOGENESIS+0.134
- BILE_ACID_METABOLISM+0.092
- HEME_METABOLISM+0.042
- COAGULATION+0.037
- WNT_BETA_CATENIN_SIGNALING+0.020
- ANDROGEN_RESPONSE-0.017
- CHOLESTEROL_HOMEOSTASIS-0.055
- ESTROGEN_RESPONSE_LATE-0.064
Top 10 suppressed
- E2F_TARGETS-0.423
- IL6_JAK_STAT3_SIGNALING-0.407
- UNFOLDED_PROTEIN_RESPONSE-0.386
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.378
- G2M_CHECKPOINT-0.378
- TGF_BETA_SIGNALING-0.374
- MYC_TARGETS_V2-0.370
- MTORC1_SIGNALING-0.355
- MYC_TARGETS_V1-0.352
- OXIDATIVE_PHOSPHORYLATION-0.349
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_2XD3MNKD | Glial-neuronal tumor NOS | — | 0.951 |
| 2 | MNG36 | — | — | 0.946 |
| 3 | MNG540 | — | — | 0.940 |
| 4 | BS_0T17SY47 | low-grade glioma | — | 0.931 |
| 5 | BS_063ERW0R | pilocytic astrocytoma | — | 0.928 |
| 6 | MNG226 | — | — | 0.926 |
| 7 | MNG1280 | — | — | 0.923 |
| 8 | BS_52MPKTJH | high-grade glioma | — | 0.921 |
| 9 | BS_3P20Q2C3 | low-grade glioma | — | 0.921 |
| 10 | BS_0Y66ZBWE | low-grade glioma | — | 0.921 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.259 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.243 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.134 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.092 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.042 | Temsirolimus | — uncovered |
| COAGULATION | 0.037 | Binimetinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.020 | Inavolisib | — uncovered |