MNG837
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.407
- ALLOGRAFT_REJECTION+0.283
- INTERFERON_ALPHA_RESPONSE+0.211
- INTERFERON_GAMMA_RESPONSE+0.162
- UV_RESPONSE_DN+0.157
- INFLAMMATORY_RESPONSE+0.140
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.126
- KRAS_SIGNALING_DN+0.121
- KRAS_SIGNALING_UP+0.110
- MYOGENESIS+0.093
Top 10 suppressed
- MYC_TARGETS_V2-0.516
- OXIDATIVE_PHOSPHORYLATION-0.503
- UNFOLDED_PROTEIN_RESPONSE-0.477
- MTORC1_SIGNALING-0.431
- MITOTIC_SPINDLE-0.426
- G2M_CHECKPOINT-0.415
- MYC_TARGETS_V1-0.384
- UV_RESPONSE_UP-0.371
- CHOLESTEROL_HOMEOSTASIS-0.367
- E2F_TARGETS-0.366
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1421198 | GTEX | — | 0.898 |
| 2 | TCGA-75-7025-01A-12R-1949-07 | — | cohortA1 | 0.896 |
| 3 | MNG1148 | — | — | 0.889 |
| 4 | SRR1413454 | GTEX | — | 0.883 |
| 5 | MNG436 | — | — | 0.881 |
| 6 | MNG1142 | — | — | 0.879 |
| 7 | MNG882 | — | — | 0.878 |
| 8 | MNG1098 | — | — | 0.876 |
| 9 | C3N-03057 | — | cohortA1 | 0.874 |
| 10 | SRR1322419 | GTEX | — | 0.872 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.407 | Cobimetinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.283 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.211 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.162 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.157 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.140 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.126 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.121 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_UP | 0.110 | Inavolisib | — uncovered |
| MYOGENESIS | 0.093 | Inavolisib | — uncovered |
| COAGULATION | 0.089 | Binimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.057 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.040 | Temsirolimus | — uncovered |