Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_JK0VPG1T

Schwannoma

1645ac2d-3b7a-517f-bbe8-e7bf18079545

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Schwannoma
cancer_type_detailed
subtype
cancer_type
Schwannoma
overall_survival_months
58.27858081471747
age_years
5.477
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.742
  • INTERFERON_GAMMA_RESPONSE+0.634
  • PROTEIN_SECRETION+0.512
  • ALLOGRAFT_REJECTION+0.445
  • APOPTOSIS+0.437
  • TNFA_SIGNALING_VIA_NFKB+0.419
  • OXIDATIVE_PHOSPHORYLATION+0.376
  • TGF_BETA_SIGNALING+0.373
  • ANDROGEN_RESPONSE+0.370
  • ADIPOGENESIS+0.364

Top 10 suppressed

  • PANCREAS_BETA_CELLS-0.373
  • HEDGEHOG_SIGNALING-0.202
  • KRAS_SIGNALING_DN-0.174
  • SPERMATOGENESIS-0.169
  • E2F_TARGETS-0.157
  • MYC_TARGETS_V2-0.109
  • G2M_CHECKPOINT-0.086
  • MYOGENESIS-0.065
  • NOTCH_SIGNALING-0.041
  • GLYCOLYSIS+0.043

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_HBJZR69P
brain-umap@2
Schwannoma0.959
2BS_H3Y8FWHV
brain-umap@2
Schwannoma0.935
3BS_CQEETJ66
brain-umap@2
Schwannoma0.935
4BS_NR9FRY5T
brain-umap@2
Schwannoma0.930
53BCD8BE5-753D-43EF-B830-EA4356620A5C
brain-umap@2
0.916
6SJEPD031215_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.914
7BS_M9C4RY4P
brain-umap@2
Schwannoma0.912
8SRR12696731
melanoma-umap@29
0.909
9SRR934811
brain-umap@2
0.907
10BS_1SVVER1H
brain-umap@2
Schwannoma0.903

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.742Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.634Idelalisib— uncovered
PROTEIN_SECRETION0.512Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.445Idelalisib— uncovered
APOPTOSIS0.437Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.419Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.376Remibrutinib— uncovered
TGF_BETA_SIGNALING0.373Inavolisib— uncovered
ANDROGEN_RESPONSE0.370Inavolisib— uncovered
ADIPOGENESIS0.364Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.344Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.341Idelalisib— uncovered
IL2_STAT5_SIGNALING0.335Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.329Idelalisib— uncovered
COMPLEMENT0.326Inavolisib— uncovered
COAGULATION0.318Binimetinib— uncovered
DNA_REPAIR0.299Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.279Remibrutinib— uncovered
MTORC1_SIGNALING0.277Inavolisib— uncovered
MYC_TARGETS_V10.273Inavolisib— uncovered