8aaaa253-87d2-4292-aeb2-1b207b71abef
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 60
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.540
- PANCREAS_BETA_CELLS+0.420
- MYOGENESIS+0.350
- HEDGEHOG_SIGNALING+0.240
- ANGIOGENESIS+0.230
- UV_RESPONSE_DN+0.200
- APICAL_JUNCTION+0.180
- COAGULATION+0.140
- KRAS_SIGNALING_DN+0.110
- ALLOGRAFT_REJECTION+0.040
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.510
- CHOLESTEROL_HOMEOSTASIS-0.430
- TNFA_SIGNALING_VIA_NFKB-0.430
- MTORC1_SIGNALING-0.400
- MYC_TARGETS_V1-0.400
- MYC_TARGETS_V2-0.380
- P53_PATHWAY-0.380
- E2F_TARGETS-0.350
- PEROXISOME-0.340
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR23303745 | — | — | 0.881 |
| 2 | SRR33346962 | — | — | 0.878 |
| 3 | SRR15069598 | — | — | 0.862 |
| 4 | SRR12475118 | — | — | 0.857 |
| 5 | SRR9879291 | — | cohortMD2 | 0.851 |
| 6 | 6b32f047-89ca-40e7-950f-a03493ea90c7 | — | — | 0.851 |
| 7 | X84315f98.9366.4174.be54.3cdd1fd9db07 | — | cohortA1 | 0.848 |
| 8 | SRR658977 | GTEX | — | 0.837 |
| 9 | d7bbb44a-3fe0-4455-99d0-90be213f2a31 | — | — | 0.833 |
| 10 | TCGA-55-8096-01A-11R-2241-07 | — | cohortA1 | 0.832 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.540 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.420 | Cobimetinib | — uncovered |
| MYOGENESIS | 0.350 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.240 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.230 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.200 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.180 | Inavolisib | — uncovered |
| COAGULATION | 0.140 | Binimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.110 | Remibrutinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.040 | Idelalisib | — uncovered |
| APICAL_SURFACE | 0.020 | Temsirolimus | — uncovered |
| HEME_METABOLISM | 0.020 | Temsirolimus | — uncovered |