Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

BS_4NWHYH53

Supratentorial Ependymoma

165471b9-0ae5-5842-a371-5960d03f5c9d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Supratentorial Ependymoma
cancer_type_detailed
—
subtype
—
cancer_type
Supratentorial Ependymoma
overall_survival_months
86.85939553219448
age_years
11.677

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.536
  • OXIDATIVE_PHOSPHORYLATION+0.405
  • INTERFERON_ALPHA_RESPONSE+0.365
  • MYC_TARGETS_V1+0.345
  • PI3K_AKT_MTOR_SIGNALING+0.321
  • DNA_REPAIR+0.305
  • UNFOLDED_PROTEIN_RESPONSE+0.269
  • INTERFERON_GAMMA_RESPONSE+0.243
  • ADIPOGENESIS+0.237
  • UV_RESPONSE_DN+0.181

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.389
  • MYOGENESIS-0.357
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.322
  • MYC_TARGETS_V2-0.318
  • APICAL_JUNCTION-0.294
  • ESTROGEN_RESPONSE_EARLY-0.229
  • APICAL_SURFACE-0.213
  • HEDGEHOG_SIGNALING-0.205
  • COAGULATION-0.193
  • ESTROGEN_RESPONSE_LATE-0.175

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_CZ3ER8DY
brain-umap@2
Supratentorial Ependymoma—0.839
2BS_W80TJC27
brain-umap@2
Supratentorial Ependymoma—0.833
3BS_CZ3NA7KV
brain-umap@2
Supratentorial Ependymoma—0.828
4BS_MT15SGJN
brain-umap@2
Supratentorial Ependymoma—0.827
5BS_KVAJYZ6F
brain-umap@2
Glial-neuronal tumor NOS—0.826
6MDT-AP-3097
medullo-epn-umap@date-based
MedMedulloblastoma0.817
7MNG398
mng-umap@100
——0.800
8BS_MT15SGJN
medullo-epn-umap@date-based
EPNSupratentorial EPN0.798
9BS_CZ3ER8DY
medullo-epn-umap@date-based
EPNSupratentorial EPN0.797
10R149
bladder-landscape@3
——0.776

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.536Remibrutinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.405Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.365Inavolisib— uncovered
MYC_TARGETS_V10.345Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.321Inavolisib— uncovered
DNA_REPAIR0.305Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.269Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.243Idelalisib— uncovered
ADIPOGENESIS0.237Inavolisib— uncovered
UV_RESPONSE_DN0.181Inavolisib— uncovered
TGF_BETA_SIGNALING0.177Inavolisib— uncovered
BILE_ACID_METABOLISM0.176Inavolisib— uncovered
PEROXISOME0.170Idelalisib— uncovered
MTORC1_SIGNALING0.158Inavolisib— uncovered
HEME_METABOLISM0.135Temsirolimus— uncovered
P53_PATHWAY0.127Idelalisib— uncovered
ANDROGEN_RESPONSE0.122Inavolisib— uncovered
APOPTOSIS0.116Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.113Inavolisib— uncovered
UV_RESPONSE_UP0.103Idelalisib— uncovered