Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AO-A12D-01A-11R-A115-07

· C

165a2e0c-5ef6-5afd-9dc9-1a017c8bf555

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C
overall_survival_months
84
os_event
false

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_1KYGSMA7
brain-umap@2
low-grade glioma0.906
2TCGA-44-7672-01A-11R-2066-07
lung-landscapes@6
cohortA10.893
3MDT-AP-3277
medullo-epn-umap@date-based
MedMedulloblastoma0.892
4ERR2278883
head-neck@1
0.890
5MBCProject_3554_T2_RNA
breast-umap@18
A0.883
6TCGA-CR-7376-01A-11R-2132-07
head-neck@1
0.877
7TCGA-AO-A03U-01B-21R-A10J-07
breast-umap@18
D0.875
8TCGA-CN-4733-01A-02R-1873-07
head-neck@1
0.873
9TCGA-CR-7394-01A-11R-2016-07
head-neck@1
0.872
10MDT-AP-3331
medullo-epn-umap@date-based
MedMedulloblastoma0.870

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.530Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.520Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.490Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.470Idelalisib— uncovered
IL2_STAT5_SIGNALING0.420Idelalisib— uncovered
KRAS_SIGNALING_UP0.420Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.390Inavolisib— uncovered
COMPLEMENT0.380Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.340Inavolisib— uncovered
COAGULATION0.330Binimetinib— uncovered
APICAL_SURFACE0.300Temsirolimus— uncovered
KRAS_SIGNALING_DN0.290Remibrutinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.290Inavolisib— uncovered
ANDROGEN_RESPONSE0.280Inavolisib— uncovered
HEDGEHOG_SIGNALING0.280Inavolisib— uncovered
ANGIOGENESIS0.240Remibrutinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.230Remibrutinib— uncovered
NOTCH_SIGNALING0.230Inavolisib— uncovered
UV_RESPONSE_DN0.210Inavolisib— uncovered
APOPTOSIS0.160Idelalisib— uncovered