Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_9DFBHHB5

low-grade glioma

1674ab96-f734-5137-a99b-97b39e6fd3e5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
low-grade glioma
cancer_type_detailed
subtype
cancer_type
low-grade glioma
overall_survival_months
58.86990801576872
age_years
0.929

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.560
  • HEDGEHOG_SIGNALING+0.542
  • INTERFERON_GAMMA_RESPONSE+0.538
  • ALLOGRAFT_REJECTION+0.521
  • TGF_BETA_SIGNALING+0.467
  • IL6_JAK_STAT3_SIGNALING+0.454
  • APICAL_SURFACE+0.390
  • INFLAMMATORY_RESPONSE+0.383
  • APOPTOSIS+0.360
  • KRAS_SIGNALING_UP+0.354

Top 10 suppressed

  • MYC_TARGETS_V2-0.425
  • E2F_TARGETS-0.257
  • OXIDATIVE_PHOSPHORYLATION-0.245
  • DNA_REPAIR-0.203
  • MYC_TARGETS_V1-0.189
  • UNFOLDED_PROTEIN_RESPONSE-0.166
  • G2M_CHECKPOINT-0.145
  • SPERMATOGENESIS-0.137
  • UV_RESPONSE_UP-0.130
  • GLYCOLYSIS-0.092

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_014EVM2D
brain-umap@2
low-grade glioma0.921
2BS_S4V9E1XJ
brain-umap@2
pilocytic astrocytoma0.915
3BS_RRAEQZ97
brain-umap@2
pilocytic astrocytoma0.909
4BS_VP5Y45Z7
brain-umap@2
pilocytic astrocytoma0.909
5TCGA-F7-8489-01A-31R-2403-07
head-neck@1
0.899
6MDT-AP-2029
medullo-epn-umap@date-based
MedMedulloblastoma0.898
7BS_JWSR581E
brain-umap@2
low-grade glioma0.896
8BS_MF9X3PKH
brain-umap@2
low-grade glioma0.896
9BS_QRNSKFMS
brain-umap@2
pilocytic astrocytoma0.889
10BS_V89HGTET
brain-umap@2
pilocytic astrocytoma0.889

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.560Inavolisib— uncovered
HEDGEHOG_SIGNALING0.542Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.538Idelalisib— uncovered
ALLOGRAFT_REJECTION0.521Idelalisib— uncovered
TGF_BETA_SIGNALING0.467Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.454Inavolisib— uncovered
APICAL_SURFACE0.390Temsirolimus— uncovered
INFLAMMATORY_RESPONSE0.383Idelalisib— uncovered
APOPTOSIS0.360Idelalisib— uncovered
KRAS_SIGNALING_UP0.354Inavolisib— uncovered
IL2_STAT5_SIGNALING0.319Idelalisib— uncovered
UV_RESPONSE_DN0.312Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.305Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.302Inavolisib— uncovered
PROTEIN_SECRETION0.301Remibrutinib— uncovered
ANGIOGENESIS0.296Remibrutinib— uncovered
COMPLEMENT0.283Inavolisib— uncovered
COAGULATION0.267Binimetinib— uncovered
MYOGENESIS0.257Inavolisib— uncovered
P53_PATHWAY0.211Idelalisib— uncovered