Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AQ-A7U7-01A-22R-A352-07

· D

1783c648-284f-57b1-9826-e38ce60c5cd4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
19

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.710
  • INTERFERON_GAMMA_RESPONSE+0.650
  • ALLOGRAFT_REJECTION+0.540
  • IL6_JAK_STAT3_SIGNALING+0.490
  • INFLAMMATORY_RESPONSE+0.450
  • TNFA_SIGNALING_VIA_NFKB+0.410
  • COMPLEMENT+0.340
  • IL2_STAT5_SIGNALING+0.320
  • WNT_BETA_CATENIN_SIGNALING+0.320
  • KRAS_SIGNALING_UP+0.310

Top 10 suppressed

  • MYC_TARGETS_V1-0.670
  • MYC_TARGETS_V2-0.630
  • OXIDATIVE_PHOSPHORYLATION-0.620
  • E2F_TARGETS-0.570
  • MTORC1_SIGNALING-0.530
  • ADIPOGENESIS-0.520
  • G2M_CHECKPOINT-0.510
  • PROTEIN_SECRETION-0.480
  • FATTY_ACID_METABOLISM-0.470
  • ANDROGEN_RESPONSE-0.400

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1X0e8b5ba7.3bee.4627.a8b6.f94263f78e3e
lung-landscapes@6
cohortMD20.950
2TCGA-93-A4JQ-01A-11R-A24X-07
lung-landscapes@6
cohortA10.938
3SRR2774280
melanoma-umap@29
0.934
4767fc312-2c66-43f7-b78e-bf79e03e3a0a
colon-landscapes@1
0.927
5TCGA-86-8671-01A-11R-2403-07
lung-landscapes@6
cohortMD20.922
6SRR8613789
breast-umap@18
A0.917
7AUR-AE6X-TTP1-A-1-0-R-A741-41
breast-umap@18
D0.916
8TCGA-C8-A8HR-01A-11R-A36F-07
breast-umap@18
A0.916
9DRR168577
bladder-landscape@3
0.914
10TCGA-98-A53C-01A-11R-A262-07
lung-landscapes@6
cohortMD20.913

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.710Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.650Idelalisib— uncovered
ALLOGRAFT_REJECTION0.540Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.490Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.450Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.410Inavolisib— uncovered
COMPLEMENT0.340Inavolisib— uncovered
IL2_STAT5_SIGNALING0.320Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.320Inavolisib— uncovered
KRAS_SIGNALING_UP0.310Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.290Inavolisib— uncovered
MYOGENESIS0.280Inavolisib— uncovered
ANGIOGENESIS0.220Remibrutinib— uncovered
COAGULATION0.220Binimetinib— uncovered
KRAS_SIGNALING_DN0.220Remibrutinib— uncovered
APICAL_JUNCTION0.150Inavolisib— uncovered
HEDGEHOG_SIGNALING0.150Inavolisib— uncovered
UV_RESPONSE_DN0.140Inavolisib— uncovered
APOPTOSIS0.070Idelalisib— uncovered
P53_PATHWAY0.060Idelalisib— uncovered