SRR10900578
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.500
- OXIDATIVE_PHOSPHORYLATION+0.500
- MYC_TARGETS_V1+0.400
- UNFOLDED_PROTEIN_RESPONSE+0.300
- DNA_REPAIR+0.200
- ADIPOGENESIS+0.100
- ANDROGEN_RESPONSE+0.100
- ESTROGEN_RESPONSE_LATE+0.100
- FATTY_ACID_METABOLISM+0.100
- ESTROGEN_RESPONSE_EARLY+0.000
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.600
- ANGIOGENESIS-0.500
- COAGULATION-0.400
- COMPLEMENT-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- MITOTIC_SPINDLE-0.400
- NOTCH_SIGNALING-0.400
- TGF_BETA_SIGNALING-0.400
- TNFA_SIGNALING_VIA_NFKB-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8518209 | — | C | 0.904 |
| 2 | SRR1313095 | — | B | 0.894 |
| 3 | 20110028.LumB | — | B | 0.880 |
| 4 | R16 | — | — | 0.879 |
| 5 | 20070010.LumB | — | B | 0.865 |
| 6 | SRR1316874 | GTEX | — | 0.862 |
| 7 | SRR5088853 | — | — | 0.862 |
| 8 | SRR1364893 | GTEX | — | 0.859 |
| 9 | SRR1313092 | — | B | 0.854 |
| 10 | TCGA-5T-A9QA-01A-11R-A41B-07 | — | B | 0.854 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.500 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.500 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.400 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.300 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.100 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.100 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |