ERR2598330
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_hindbrain
- 23
- umap1_2d
- -4.785495418
- umap2_2d
- -3.633458454
- umap1_3d
- 3.62016944
- umap2_3d
- 1.516501391
- umap3_3d
- -0.600728508
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.400
- OXIDATIVE_PHOSPHORYLATION+0.390
- INTERFERON_GAMMA_RESPONSE+0.350
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.260
- ADIPOGENESIS+0.250
- BILE_ACID_METABOLISM+0.230
- FATTY_ACID_METABOLISM+0.190
- PROTEIN_SECRETION+0.190
- XENOBIOTIC_METABOLISM+0.190
- MYOGENESIS+0.170
Top 10 suppressed
- G2M_CHECKPOINT-0.570
- E2F_TARGETS-0.560
- MYC_TARGETS_V1-0.510
- WNT_BETA_CATENIN_SIGNALING-0.490
- HEDGEHOG_SIGNALING-0.440
- MYC_TARGETS_V2-0.440
- TGF_BETA_SIGNALING-0.420
- MITOTIC_SPINDLE-0.380
- ANGIOGENESIS-0.300
- UNFOLDED_PROTEIN_RESPONSE-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598272 | fetal | fetal | 0.931 |
| 2 | ERR2598274 | fetal | fetal | 0.928 |
| 3 | ERR2598271 | fetal | fetal | 0.924 |
| 4 | ERR2598331 | fetal | fetal | 0.919 |
| 5 | EPT0505 | EPN | EPN Tumor | 0.864 |
| 6 | ERR2598340 | fetal | fetal | 0.855 |
| 7 | TCGA-50-6597-01A-11R-1858-07 | — | cohortA1 | 0.851 |
| 8 | ERR2598273 | fetal | fetal | 0.849 |
| 9 | ERR2598267 | fetal | fetal | 0.847 |
| 10 | ERR2598281 | fetal | fetal | 0.843 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 22 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.400 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.390 | Remibrutinib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.350 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.260 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.250 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.230 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.190 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.190 | Remibrutinib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.190 | Inavolisib | — uncovered |
| MYOGENESIS | 0.170 | Inavolisib | — uncovered |
| COMPLEMENT | 0.160 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.140 | Temsirolimus | — uncovered |
| INFLAMMATORY_RESPONSE | 0.130 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.130 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.120 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.120 | Remibrutinib | — uncovered |
| PEROXISOME | 0.080 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.060 | Inavolisib | — uncovered |
| COAGULATION | 0.040 | Binimetinib | — uncovered |
| P53_PATHWAY | 0.040 | Idelalisib | — uncovered |