Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-CV-6952-01A-11R-1915-07

1c407c85-1eb3-5ee8-a878-18dc3e639935

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.042237443
sex
female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.730
  • INTERFERON_GAMMA_RESPONSE+0.600
  • TNFA_SIGNALING_VIA_NFKB+0.430
  • PROTEIN_SECRETION+0.380
  • IL6_JAK_STAT3_SIGNALING+0.350
  • CHOLESTEROL_HOMEOSTASIS+0.340
  • INFLAMMATORY_RESPONSE+0.340
  • MYOGENESIS+0.340
  • TGF_BETA_SIGNALING+0.330
  • ALLOGRAFT_REJECTION+0.310

Top 10 suppressed

  • E2F_TARGETS-0.260
  • SPERMATOGENESIS-0.260
  • PEROXISOME-0.220
  • OXIDATIVE_PHOSPHORYLATION-0.170
  • ADIPOGENESIS-0.160
  • G2M_CHECKPOINT-0.160
  • PANCREAS_BETA_CELLS-0.140
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.130
  • DNA_REPAIR-0.090
  • BILE_ACID_METABOLISM-0.070

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-CQ-A4C6-01A-11R-A24Z-07
head-neck@1
0.875
2SRR25043629
head-neck@1
0.858
3BS_5AF6ZNJF
brain-umap@2
Meningioma0.843
4BS_E94QRJDW
brain-umap@2
low-grade glioma0.835
5TCGA-CN-6998-01A-23R-2016-07
head-neck@1
0.829
6BS_X91K8KMG
brain-umap@2
pilocytic astrocytoma0.828
7TCGA-K4-A6FZ-01A-11R-A31N-07
bladder-landscape@3
0.823
8TCGA-CR-7395-01A-11R-2016-07
head-neck@1
0.823
9BS_HX0S30NE
brain-umap@2
pilocytic astrocytoma0.823
10TCGA-CQ-7063-01A-11R-2403-07
head-neck@1
0.821

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.730Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.600Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.430Inavolisib— uncovered
PROTEIN_SECRETION0.380Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.350Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.340Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.340Idelalisib— uncovered
MYOGENESIS0.340Inavolisib— uncovered
TGF_BETA_SIGNALING0.330Inavolisib— uncovered
ALLOGRAFT_REJECTION0.310Idelalisib— uncovered
COMPLEMENT0.310Inavolisib— uncovered
P53_PATHWAY0.280Idelalisib— uncovered
KRAS_SIGNALING_UP0.260Inavolisib— uncovered
APICAL_JUNCTION0.250Inavolisib— uncovered
APOPTOSIS0.250Idelalisib— uncovered
IL2_STAT5_SIGNALING0.240Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.240Inavolisib— uncovered
ANDROGEN_RESPONSE0.210Inavolisib— uncovered
HYPOXIA0.210Idelalisib— uncovered
GLYCOLYSIS0.200Inavolisib— uncovered