Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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53bd217b-0458-4315-a13c-f9e79fa46501

1c8fc477-7256-56a2-94f8-d0c19d864a13

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
42.1957563312799

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_BVSW4GTG
brain-umap@2
medulloblastoma0.884
2de19e3c1-3508-4c13-b2cf-7079ee934a55
melanoma-umap@29
0.878
3BS_81SP2HX4
brain-umap@2
medulloblastoma0.872
4TCGA-50-6591-01A-11R-1755-07
lung-landscapes@6
cohortMD10.868
532a88c36-6b9a-483f-ad00-bf899ae279ba
melanoma-umap@29
0.868
6BS_1QXEC43H
brain-umap@2
medulloblastoma0.867
7SRR5088819
melanoma-umap@29
0.863
8TCGA-34-5927-01A-11R-1820-07
lung-landscapes@6
cohortSQ10.863
9SAMN03290918
melanoma-umap@29
0.862
10BS_AMZ70B6F
brain-umap@2
medulloblastoma0.862

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.610Idelalisib— uncovered
G2M_CHECKPOINT0.580Inavolisib— uncovered
E2F_TARGETS0.570Inavolisib— uncovered
MYC_TARGETS_V10.430Inavolisib— uncovered
MITOTIC_SPINDLE0.390Inavolisib— uncovered
HEDGEHOG_SIGNALING0.250Inavolisib— uncovered
SPERMATOGENESIS0.160Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.160Idelalisib— uncovered
UV_RESPONSE_DN0.110Inavolisib— uncovered
PANCREAS_BETA_CELLS0.100Cobimetinib— uncovered
APICAL_JUNCTION0.090Inavolisib— uncovered
APICAL_SURFACE0.070Temsirolimus— uncovered
NOTCH_SIGNALING0.060Inavolisib— uncovered
DNA_REPAIR0.050Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.010Inavolisib— uncovered
MTORC1_SIGNALING0.010Inavolisib— uncovered
MYOGENESIS0.010Inavolisib— uncovered