SRR819370
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.268
- BILE_ACID_METABOLISM+0.220
- PANCREAS_BETA_CELLS+0.196
- PEROXISOME+0.189
- SPERMATOGENESIS+0.171
- FATTY_ACID_METABOLISM+0.169
- KRAS_SIGNALING_DN+0.160
- CHOLESTEROL_HOMEOSTASIS+0.158
- OXIDATIVE_PHOSPHORYLATION+0.123
- APICAL_JUNCTION+0.077
Top 10 suppressed
- MYC_TARGETS_V2-0.529
- IL6_JAK_STAT3_SIGNALING-0.508
- TNFA_SIGNALING_VIA_NFKB-0.482
- E2F_TARGETS-0.398
- G2M_CHECKPOINT-0.398
- INTERFERON_GAMMA_RESPONSE-0.366
- ALLOGRAFT_REJECTION-0.359
- UNFOLDED_PROTEIN_RESPONSE-0.349
- INTERFERON_ALPHA_RESPONSE-0.328
- MYC_TARGETS_V1-0.304
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1339387 | GTEX | — | 0.926 |
| 2 | SRR818086 | GTEX | — | 0.904 |
| 3 | SRR1387809 | GTEX | — | 0.895 |
| 4 | SRR1447693 | GTEX | — | 0.883 |
| 5 | SRR1416999 | GTEX | — | 0.862 |
| 6 | SRR1486626 | GTEX | — | 0.861 |
| 7 | SRR1316963 | GTEX | — | 0.861 |
| 8 | SRR661779 | GTEX | — | 0.860 |
| 9 | BS_67Z63A2K | EPN | Posterior Fossa EPN | 0.857 |
| 10 | SRR1336158 | GTEX | — | 0.854 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.268 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.220 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.196 | Cobimetinib | — uncovered |
| PEROXISOME | 0.189 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.171 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.169 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.160 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.158 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.123 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.077 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.069 | Temsirolimus | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.042 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.042 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.034 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.009 | Inavolisib | — uncovered |