Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR8613703

· D

1e845d0e-a349-5d22-b0e5-9127ba8987b7

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8613779
breast-umap@18
D0.907
2TCGA-56-8626-01A-11R-2403-07
lung-landscapes@6
cohortSQ10.902
3TCGA-DK-A3IQ-01A-31R-A32Y-07
bladder-landscape@3
0.900
4544dbca2-f436-4cb7-9e11-572ead91d28d
colon-landscapes@1
0.899
5TCGA-HN-A2OB-01A-21R-A27Q-07
breast-umap@18
A0.893
6SRR8518453
breast-umap@18
F0.889
7s0122297
melanoma-umap@29
0.888
8TCGA-P6-A5OF-01
acc-tcga-pancan-2018@2018
Adrenocortical CarcinomaAdrenocortical Carcinoma, Usual Type0.887
920040084.LumA
breast-umap@18
A0.882
10SRR11296795
colon-landscapes@1
0.878

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 21 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
HEDGEHOG_SIGNALING0.590Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.540Inavolisib— uncovered
MYOGENESIS0.490Inavolisib— uncovered
ANGIOGENESIS0.460Remibrutinib— uncovered
APICAL_JUNCTION0.440Inavolisib— uncovered
UV_RESPONSE_DN0.440Inavolisib— uncovered
TGF_BETA_SIGNALING0.410Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.390Inavolisib— uncovered
HYPOXIA0.370Idelalisib— uncovered
APICAL_SURFACE0.340Temsirolimus— uncovered
COAGULATION0.330Binimetinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.260Remibrutinib— uncovered
NOTCH_SIGNALING0.260Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.190Inavolisib— uncovered
KRAS_SIGNALING_DN0.150Remibrutinib— uncovered
KRAS_SIGNALING_UP0.130Inavolisib— uncovered
BILE_ACID_METABOLISM0.080Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.080Idelalisib— uncovered
GLYCOLYSIS0.070Inavolisib— uncovered
HEME_METABOLISM0.030Temsirolimus— uncovered