Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AN-A0XN-01A-21R-A109-07

· A

1f152690-f2d6-5185-8e7a-aab3a2e85742

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
0
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.690
  • HEDGEHOG_SIGNALING+0.490
  • INFLAMMATORY_RESPONSE+0.490
  • ANGIOGENESIS+0.480
  • TGF_BETA_SIGNALING+0.480
  • TNFA_SIGNALING_VIA_NFKB+0.460
  • UV_RESPONSE_DN+0.460
  • HYPOXIA+0.450
  • KRAS_SIGNALING_UP+0.410
  • COAGULATION+0.380

Top 10 suppressed

  • DNA_REPAIR-0.400
  • E2F_TARGETS-0.360
  • OXIDATIVE_PHOSPHORYLATION-0.340
  • MYC_TARGETS_V1-0.290
  • MYC_TARGETS_V2-0.280
  • PEROXISOME-0.270
  • G2M_CHECKPOINT-0.250
  • FATTY_ACID_METABOLISM-0.210
  • BILE_ACID_METABOLISM-0.180
  • ADIPOGENESIS-0.150

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-E9-A1NG-01A-21R-A14M-07
breast-umap@18
A0.934
2SRR26320074
bladder-landscape@3
0.913
3TCGA-43-6647-01A-11R-1820-07
lung-landscapes@6
cohortSQ10.911
4TCGA-CR-6474-01A-11R-1873-07
head-neck@1
0.896
5TCGA-DK-A1AF-01A-11R-A13Y-07
bladder-landscape@3
0.890
6TCGA-46-3767-01A-01R-0980-07
lung-landscapes@6
cohortSQ10.881
7SRR15069613
head-neck@1
0.880
8X17a4d870.71ef.4580.91db.071219517f26
lung-landscapes@6
cohortSQ10.876
9SRR23303737
bladder-landscape@3
0.872
10TCGA-64-5815-01A-01R-1628-07
lung-landscapes@6
cohortA10.871

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 36 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.690Inavolisib— uncovered
HEDGEHOG_SIGNALING0.490Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.490Idelalisib— uncovered
ANGIOGENESIS0.480Remibrutinib— uncovered
TGF_BETA_SIGNALING0.480Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.460Inavolisib— uncovered
UV_RESPONSE_DN0.460Inavolisib— uncovered
HYPOXIA0.450Idelalisib— uncovered
KRAS_SIGNALING_UP0.410Inavolisib— uncovered
COAGULATION0.380Binimetinib— uncovered
COMPLEMENT0.370Inavolisib— uncovered
ALLOGRAFT_REJECTION0.360Idelalisib— uncovered
NOTCH_SIGNALING0.360Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.350Inavolisib— uncovered
ANDROGEN_RESPONSE0.330Inavolisib— uncovered
IL2_STAT5_SIGNALING0.320Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.310Inavolisib— uncovered
APICAL_JUNCTION0.270Inavolisib— uncovered
PROTEIN_SECRETION0.270Remibrutinib— uncovered
APOPTOSIS0.250Idelalisib— uncovered