Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · bladder-landscape@3

SRR8942959

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213302b0-f8ba-58fc-9a45-1539d20a1209

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1R309
bladder-landscape@3
——0.880
2AUR-AFUM-TTM1-A-1-1-R-A743-41
breast-umap@18
—E0.875
3AUR-AF95-TTM1-A-1-1-R-A742-41
breast-umap@18
—E0.870
4TCGA-66-2781-01A-01R-0851-07
lung-landscapes@6
—cohortSQ20.848
5TCGA-YC-A9TC-01A-22R-A39I-07
bladder-landscape@3
——0.847
6s0112274
melanoma-umap@29
——0.844
7fddf611e-f586-49e1-9ee8-8ac853accb9e
colon-landscapes@1
——0.842
8SRR8518376
breast-umap@18
—E0.833
9TCGA-B6-A0I1-01A-11R-A21T-07
breast-umap@18
—E0.831
10TCGA-56-8304-01A-11R-2326-07
lung-landscapes@6
—cohortSQ10.825

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.570Idelalisib— uncovered
E2F_TARGETS0.350Inavolisib— uncovered
MYC_TARGETS_V10.330Inavolisib— uncovered
FATTY_ACID_METABOLISM0.300Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.300Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.300Inavolisib— uncovered
SPERMATOGENESIS0.280Inavolisib— uncovered
G2M_CHECKPOINT0.230Inavolisib— uncovered
GLYCOLYSIS0.230Inavolisib— uncovered
KRAS_SIGNALING_DN0.190Remibrutinib— uncovered
UV_RESPONSE_UP0.190Idelalisib— uncovered
ADIPOGENESIS0.180Inavolisib— uncovered
DNA_REPAIR0.180Idelalisib— uncovered
MTORC1_SIGNALING0.170Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.150Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.150Idelalisib— uncovered
PEROXISOME0.150Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.150Idelalisib— uncovered
HYPOXIA0.100Idelalisib— uncovered
PANCREAS_BETA_CELLS0.100Cobimetinib— uncovered