Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-CV-5444-01A-02R-1514-07

2213b329-b607-5d44-8dd7-cb51a17022b8

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
144eb0b78-9761-4131-b831-85e765a24e6b
colon-landscapes@1
0.930
2TCGA-K4-A3WS-01A-11R-A22U-07
bladder-landscape@3
0.909
320040019.LumA
breast-umap@18
A0.904
4TCGA-DK-AA6S-01A-21R-A39I-07
bladder-landscape@3
0.901
5TCGA-QK-A8Z9-01B-11R-A39I-07
head-neck@1
0.901
6SRR6013599
lung-landscapes@6
cohortMD20.899
7SRR26320092
bladder-landscape@3
0.894
8SRR2932812
head-neck@1
0.890
9TCGA-97-8547-01A-11R-2403-07
lung-landscapes@6
cohortA10.890
10ERR2278882
head-neck@1
0.890

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYOGENESIS0.550Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.540Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.510Inavolisib— uncovered
ANGIOGENESIS0.370Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.360Idelalisib— uncovered
PANCREAS_BETA_CELLS0.310Cobimetinib— uncovered
COAGULATION0.290Binimetinib— uncovered
UV_RESPONSE_DN0.290Inavolisib— uncovered
HEDGEHOG_SIGNALING0.280Inavolisib— uncovered
NOTCH_SIGNALING0.250Inavolisib— uncovered
KRAS_SIGNALING_DN0.240Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.210Idelalisib— uncovered
KRAS_SIGNALING_UP0.200Inavolisib— uncovered
COMPLEMENT0.180Inavolisib— uncovered
APICAL_JUNCTION0.170Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.150Idelalisib— uncovered
IL2_STAT5_SIGNALING0.100Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.100Inavolisib— uncovered
TGF_BETA_SIGNALING0.090Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.070Inavolisib— uncovered