SRR614647
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.319
- OXIDATIVE_PHOSPHORYLATION+0.312
- PANCREAS_BETA_CELLS+0.261
- KRAS_SIGNALING_DN+0.210
- UV_RESPONSE_DN+0.187
- MYOGENESIS+0.165
- SPERMATOGENESIS+0.154
- FATTY_ACID_METABOLISM+0.087
- BILE_ACID_METABOLISM+0.085
- HEME_METABOLISM+0.024
Top 10 suppressed
- MYC_TARGETS_V2-0.529
- INTERFERON_ALPHA_RESPONSE-0.511
- IL6_JAK_STAT3_SIGNALING-0.503
- TNFA_SIGNALING_VIA_NFKB-0.495
- E2F_TARGETS-0.466
- G2M_CHECKPOINT-0.459
- INTERFERON_GAMMA_RESPONSE-0.455
- ANGIOGENESIS-0.432
- UNFOLDED_PROTEIN_RESPONSE-0.401
- MYC_TARGETS_V1-0.399
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_TG93XC55 | Ganglioglioma | — | 0.956 |
| 2 | SRR1395834 | GTEX | — | 0.948 |
| 3 | SRR1470703 | GTEX | — | 0.947 |
| 4 | SRR1416999 | GTEX | — | 0.945 |
| 5 | SRR1434526 | GTEX | — | 0.945 |
| 6 | BS_AJ6X83G5 | DNET | — | 0.945 |
| 7 | SRR1317877 | GTEX | — | 0.944 |
| 8 | BS_WCRKYV0T | low-grade glioma | — | 0.944 |
| 9 | SRR1476676 | GTEX | — | 0.944 |
| 10 | SRR1447693 | GTEX | — | 0.940 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.319 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.312 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.261 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.210 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.187 | Inavolisib | — uncovered |
| MYOGENESIS | 0.165 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.154 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.087 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.085 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.024 | Temsirolimus | — uncovered |