ERR2598070
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_forebrain
- 11
- umap1_2d
- -4.370530631
- umap2_2d
- 1.90792246
- umap1_3d
- -2.326832479
- umap2_3d
- 2.318280164
- umap3_3d
- -2.529260597
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.580
- MYC_TARGETS_V1+0.570
- G2M_CHECKPOINT+0.540
- MYC_TARGETS_V2+0.530
- DNA_REPAIR+0.480
- UNFOLDED_PROTEIN_RESPONSE+0.290
- CHOLESTEROL_HOMEOSTASIS+0.280
- MITOTIC_SPINDLE+0.260
- OXIDATIVE_PHOSPHORYLATION+0.240
- MTORC1_SIGNALING+0.230
Top 10 suppressed
- INFLAMMATORY_RESPONSE-0.370
- APICAL_SURFACE-0.270
- KRAS_SIGNALING_DN-0.270
- ALLOGRAFT_REJECTION-0.240
- INTERFERON_GAMMA_RESPONSE-0.200
- INTERFERON_ALPHA_RESPONSE-0.190
- COMPLEMENT-0.170
- ESTROGEN_RESPONSE_LATE-0.160
- IL6_JAK_STAT3_SIGNALING-0.150
- BILE_ACID_METABOLISM-0.120
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598051 | fetal | fetal | 0.901 |
| 2 | ERR2598069 | fetal | fetal | 0.865 |
| 3 | E0DE33EA-C3DF-478E-9C4D-86E3C7B3A1D9 | — | — | 0.858 |
| 4 | MDT-AP-0359 | Med | Medulloblastoma | 0.857 |
| 5 | MDT-AP-2110 | Med | Medulloblastoma | 0.855 |
| 6 | ERR2598252 | fetal | fetal | 0.855 |
| 7 | 93123F83-44EC-4480-9453-F061AA7BC2DB | — | — | 0.853 |
| 8 | SRR12696786 | — | — | 0.850 |
| 9 | d9eacc36-0ae3-41bd-aef6-503f91cb25aa | — | — | 0.842 |
| 10 | MNG925 | — | — | 0.839 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 28 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.580 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.570 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.540 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.530 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.480 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.290 | Idelalisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.280 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.260 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.240 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.230 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.190 | Temsirolimus | — uncovered |
| ADIPOGENESIS | 0.160 | Inavolisib | — uncovered |
| PEROXISOME | 0.160 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.150 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.140 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.130 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.120 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.100 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.090 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.080 | Inavolisib | — uncovered |