cfda240e-d071-418b-9a7d-a6fd30e60cdf
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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- age_years
- 64
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_5P1TN10Z | Embryonal tumors | — | 0.912 |
| 2 | MDT-AP-3401 | Med | Medulloblastoma | 0.895 |
| 3 | TCGA-56-7730-01A-11R-2125-07 | — | cohortSQ2 | 0.891 |
| 4 | BS_K25F4J3V | ATRT | — | 0.891 |
| 5 | MNG704 | — | — | 0.891 |
| 6 | SRR10900597 | — | — | 0.888 |
| 7 | TCGA-66-2793-01A-01R-1201-07 | — | cohortMD1 | 0.886 |
| 8 | SRR650141 | — | — | 0.883 |
| 9 | TCGA-63-7023-01A-11R-1949-07 | — | cohortSQ2 | 0.881 |
| 10 | BS_8SKZ7BRN | low-grade glioma | — | 0.880 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.580 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.550 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.520 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.450 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.350 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.270 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.230 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.210 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.140 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.110 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.080 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.050 | Inavolisib | — uncovered |
| PEROXISOME | 0.020 | Idelalisib | — uncovered |