SRR1333694
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- CHOLESTEROL_HOMEOSTASIS+0.447
- INTERFERON_ALPHA_RESPONSE+0.405
- INTERFERON_GAMMA_RESPONSE+0.304
- PROTEIN_SECRETION+0.271
- IL2_STAT5_SIGNALING+0.252
- IL6_JAK_STAT3_SIGNALING+0.245
- ALLOGRAFT_REJECTION+0.241
- INFLAMMATORY_RESPONSE+0.241
- BILE_ACID_METABOLISM+0.234
- TNFA_SIGNALING_VIA_NFKB+0.232
Top 10 suppressed
- HEDGEHOG_SIGNALING-0.380
- PANCREAS_BETA_CELLS-0.343
- MYC_TARGETS_V2-0.264
- KRAS_SIGNALING_DN-0.239
- OXIDATIVE_PHOSPHORYLATION-0.231
- G2M_CHECKPOINT-0.194
- E2F_TARGETS-0.191
- UV_RESPONSE_DN-0.179
- NOTCH_SIGNALING-0.162
- SPERMATOGENESIS-0.120
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1486304 | GTEX | — | 0.950 |
| 2 | SRR1413768 | GTEX | — | 0.929 |
| 3 | SRR1488172 | GTEX | — | 0.922 |
| 4 | SRR1429244 | GTEX | — | 0.910 |
| 5 | SRR1085782 | GTEX | — | 0.889 |
| 6 | SRR1402840 | GTEX | — | 0.888 |
| 7 | SRR1402882 | GTEX | — | 0.875 |
| 8 | SRR1092706 | GTEX | — | 0.860 |
| 9 | SRR1446828 | GTEX | — | 0.860 |
| 10 | SRR1458595 | GTEX | — | 0.853 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 30 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 0.447 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.405 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.304 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.271 | Remibrutinib | — uncovered |
| IL2_STAT5_SIGNALING | 0.252 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.245 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.241 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.241 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.234 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.232 | Inavolisib | — uncovered |
| PEROXISOME | 0.219 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.205 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.205 | Inavolisib | — uncovered |
| APOPTOSIS | 0.200 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.190 | Inavolisib | — uncovered |
| COMPLEMENT | 0.161 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.129 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.122 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_UP | 0.108 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.075 | Idelalisib | — uncovered |