Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR15030861

281ad481-b6ff-5c06-b404-77d91ed0cc8f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR33532822
breast-umap@18
C0.865
2SRR6013498
lung-landscapes@6
cohortA10.859
3BS_JG9JZTA9
brain-umap@2
low-grade glioma0.858
4D06FFD0C-80D4-413D-9C83-62D9C163EDAB
brain-umap@2
0.851
5SRR8942975
bladder-landscape@3
0.843
6SRR8942937
bladder-landscape@3
0.841
79BB56866-4E99-4E8A-A63F-2D4801558F14
brain-umap@2
0.841
8B9535625-504A-4FCD-B341-2985AE72508A
brain-umap@2
0.840
9BS_M8WP5T16
brain-umap@2
low-grade glioma0.839
10A0396799-AB5C-401F-81FF-7C829A3CF1E4
brain-umap@2
0.838

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 42 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.650Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.580Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.550Idelalisib— uncovered
COAGULATION0.470Binimetinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.450Remibrutinib— uncovered
ADIPOGENESIS0.390Inavolisib— uncovered
BILE_ACID_METABOLISM0.390Inavolisib— uncovered
PEROXISOME0.390Idelalisib— uncovered
FATTY_ACID_METABOLISM0.380Inavolisib— uncovered
MYC_TARGETS_V20.380Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.360Inavolisib— uncovered
ALLOGRAFT_REJECTION0.350Idelalisib— uncovered
UV_RESPONSE_UP0.350Idelalisib— uncovered
COMPLEMENT0.330Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.320Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.320Inavolisib— uncovered
MYC_TARGETS_V10.320Inavolisib— uncovered
E2F_TARGETS0.300Inavolisib— uncovered
APOPTOSIS0.290Idelalisib— uncovered
DNA_REPAIR0.280Idelalisib— uncovered