SRR6013541

— · cohortSQ1

282f3d49-2a9e-5332-95a3-f6695b95e412

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortSQ1
subtype: cohortSQ1

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	MDT-AP-3189 medullo-epn-umap@date-based	Med	Medulloblastoma	0.915
2	BS_JT82QGXF brain-umap@2	medulloblastoma	—	0.912
3	BS_YMAJC22S brain-umap@2	low-grade glioma	—	0.907
4	MNG1257 mng-umap@100	—	—	0.904
5	MNG189 mng-umap@100	—	—	0.900
6	SRR23303774 bladder-landscape@3	—	—	0.899
7	SRR1797291 lung-landscapes@6	—	cohortSC	0.892
8	BS_Q13FQ8FV brain-umap@2	Diffuse intrinsic pontine glioma	—	0.891
9	SRR22247242 lung-landscapes@6	—	cohortSC	0.890
10	TCGA-56-A5DS-01A-11R-A27Q-07 lung-landscapes@6	—	cohortSQ1	0.888

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 9 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
KRAS_SIGNALING_DN	0.340	Remibrutinib	— uncovered
E2F_TARGETS	0.230	Inavolisib	— uncovered
APICAL_SURFACE	0.220	Temsirolimus	— uncovered
G2M_CHECKPOINT	0.210	Inavolisib	— uncovered
SPERMATOGENESIS	0.190	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.170	Cobimetinib	— uncovered
HEDGEHOG_SIGNALING	0.120	Inavolisib	— uncovered
ESTROGEN_RESPONSE_LATE	0.110	Idelalisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.080	Inavolisib	— uncovered