5b217223-8b43-47b6-a694-c808b643c3c3
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 74
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.430
- G2M_CHECKPOINT+0.380
- MITOTIC_SPINDLE+0.290
- INTERFERON_ALPHA_RESPONSE+0.250
- INTERFERON_GAMMA_RESPONSE+0.180
- PANCREAS_BETA_CELLS+0.170
- SPERMATOGENESIS+0.140
- GLYCOLYSIS+0.030
- ESTROGEN_RESPONSE_LATE+0.010
- ALLOGRAFT_REJECTION+0.000
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.470
- COAGULATION-0.340
- OXIDATIVE_PHOSPHORYLATION-0.340
- APICAL_JUNCTION-0.320
- NOTCH_SIGNALING-0.310
- MYOGENESIS-0.290
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.290
- ADIPOGENESIS-0.280
- MYC_TARGETS_V2-0.280
- TGF_BETA_SIGNALING-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-P3-A5QE-01A-11R-A28V-07 | — | — | 0.839 |
| 2 | TCGA-55-A4DF-01A-11R-A24H-07 | — | cohortA3 | 0.828 |
| 3 | SRR10899995 | — | — | 0.799 |
| 4 | SRR15030894 | — | — | 0.780 |
| 5 | SRR12202426 | — | — | 0.778 |
| 6 | SRR650131 | — | — | 0.762 |
| 7 | TCGA-QK-A6V9-01A-11R-A34R-07 | — | — | 0.756 |
| 8 | SRR2016968 | — | — | 0.755 |
| 9 | SRR650133 | — | — | 0.750 |
| 10 | ERR2208907 | — | — | 0.746 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.430 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.380 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.290 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.250 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.180 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.170 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.140 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.030 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.010 | Idelalisib | — uncovered |