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TCGA-B6-A0X7-01A-11R-A10J-07

· A

2a97b694-02fe-5219-8457-9bcaa676e438

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
59

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • UV_RESPONSE_DN+0.190
  • ANGIOGENESIS+0.140
  • TGF_BETA_SIGNALING+0.130
  • MYOGENESIS+0.090
  • NOTCH_SIGNALING+0.090
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.080
  • PANCREAS_BETA_CELLS+0.070
  • BILE_ACID_METABOLISM+0.030
  • ADIPOGENESIS+0.000
  • HEME_METABOLISM-0.040

Top 10 suppressed

  • E2F_TARGETS-0.580
  • G2M_CHECKPOINT-0.550
  • ALLOGRAFT_REJECTION-0.540
  • MTORC1_SIGNALING-0.510
  • TNFA_SIGNALING_VIA_NFKB-0.500
  • INFLAMMATORY_RESPONSE-0.470
  • COMPLEMENT-0.430
  • IL6_JAK_STAT3_SIGNALING-0.390
  • MYC_TARGETS_V2-0.390
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.390

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3N-01409
lung-landscapes@6
cohortA10.895
2MNG770
mng-umap@100
0.872
3TCGA-78-7161-01A-11R-2039-07
lung-landscapes@6
cohortA30.872
4C3L-02165
lung-landscapes@6
cohortA20.870
5SRR6013544
lung-landscapes@6
cohortA10.863
6SRR8518225
breast-umap@18
B0.861
7e3d71c3f-4e56-45fa-be88-2cf444b70a5c
melanoma-umap@29
0.861
8TCGA-D8-A73X-01A-11R-A32P-07
breast-umap@18
B0.855
9d69e622a-6dee-48f3-bf06-7f6148d7472a
colon-landscapes@1
0.854
10C3N-03420
lung-landscapes@6
cohortA10.852

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 8 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UV_RESPONSE_DN0.190Inavolisib— uncovered
ANGIOGENESIS0.140Remibrutinib— uncovered
TGF_BETA_SIGNALING0.130Inavolisib— uncovered
MYOGENESIS0.090Inavolisib— uncovered
NOTCH_SIGNALING0.090Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.080Inavolisib— uncovered
PANCREAS_BETA_CELLS0.070Cobimetinib— uncovered
BILE_ACID_METABOLISM0.030Inavolisib— uncovered