SRR598533

GTEX

2abb38ae-b0a7-5cbe-a188-1027879cf361

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: GTEX
cancer_type_detailed: —
subtype: —
cancer_type: GTEX
sex: Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

KRAS_SIGNALING_DN+0.339
ALLOGRAFT_REJECTION+0.190
SPERMATOGENESIS+0.171
PANCREAS_BETA_CELLS+0.094
MYOGENESIS-0.033
IL6_JAK_STAT3_SIGNALING-0.038
APICAL_SURFACE-0.042
APICAL_JUNCTION-0.072
INFLAMMATORY_RESPONSE-0.077
E2F_TARGETS-0.101

Top 10 suppressed

OXIDATIVE_PHOSPHORYLATION-0.614
ADIPOGENESIS-0.516
TGF_BETA_SIGNALING-0.511
FATTY_ACID_METABOLISM-0.480
REACTIVE_OXYGEN_SPECIES_PATHWAY-0.475
MYC_TARGETS_V1-0.458
NOTCH_SIGNALING-0.457
MTORC1_SIGNALING-0.455
CHOLESTEROL_HOMEOSTASIS-0.451
HEDGEHOG_SIGNALING-0.438

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR602753 brain-umap@2	GTEX	—	0.972
2	SRR1452056 brain-umap@2	GTEX	—	0.961
3	SRR1439674 brain-umap@2	GTEX	—	0.952
4	SRR1485789 brain-umap@2	GTEX	—	0.952
5	SRR1471374 brain-umap@2	GTEX	—	0.937
6	SRR1435884 brain-umap@2	GTEX	—	0.928
7	SRR1479912 brain-umap@2	GTEX	—	0.927
8	MNG555 mng-umap@100	—	—	0.925
9	SRR627425 brain-umap@2	GTEX	—	0.925
10	SRR8942981 bladder-landscape@3	—	—	0.919

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
KRAS_SIGNALING_DN	0.339	Remibrutinib	— uncovered
ALLOGRAFT_REJECTION	0.190	Idelalisib	— uncovered
SPERMATOGENESIS	0.171	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.094	Cobimetinib	— uncovered