Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR4195649

2b20cdd6-3cfb-5ed8-b342-30206b8a77d4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2208910
melanoma-umap@29
0.860
2R38
bladder-landscape@3
0.813
3R168
bladder-landscape@3
0.808
469d9a82b-5c37-45bd-a1cf-ffe1392e84fc
melanoma-umap@29
0.808
5d496ef4f-4716-4e6e-94e3-fce93b26d4ee
colon-landscapes@1
0.804
6SRR12475145
colon-landscapes@1
0.803
73843de1d-0eaa-48af-be58-903fcf2e5f89
colon-landscapes@1
0.802
820020085.TNBC
breast-umap@18
F0.798
9MNG74
mng-umap@100
0.797
10R37
bladder-landscape@3
0.793

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
WNT_BETA_CATENIN_SIGNALING0.410Inavolisib— uncovered
TGF_BETA_SIGNALING0.310Inavolisib— uncovered
HEDGEHOG_SIGNALING0.280Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.240Inavolisib— uncovered
HYPOXIA0.230Idelalisib— uncovered
NOTCH_SIGNALING0.230Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.230Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.210Inavolisib— uncovered
MYOGENESIS0.200Inavolisib— uncovered
P53_PATHWAY0.200Idelalisib— uncovered
APICAL_JUNCTION0.190Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.190Inavolisib— uncovered
UV_RESPONSE_UP0.190Idelalisib— uncovered
ANGIOGENESIS0.180Remibrutinib— uncovered
APICAL_SURFACE0.160Temsirolimus— uncovered
KRAS_SIGNALING_DN0.160Remibrutinib— uncovered
COAGULATION0.140Binimetinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.140Inavolisib— uncovered
IL2_STAT5_SIGNALING0.100Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.090Inavolisib— uncovered