BS_196BBNEJ
Posterior Fossa Ependymoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Posterior Fossa Ependymoma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- Posterior Fossa Ependymoma
- overall_survival_months
- 51.6754270696452
- age_years
- 1.03
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_196BBNEJ | EPN | Posterior Fossa EPN | 0.913 |
| 2 | BS_J8VX4D17 | Posterior Fossa Ependymoma | — | 0.833 |
| 3 | BS_RHD7XPNP | Posterior Fossa Ependymoma | — | 0.826 |
| 4 | 40b92a76-f324-4cdd-8209-517d021acd47 | — | — | 0.823 |
| 5 | s0112232 | — | — | 0.807 |
| 6 | BS_QP6MSKRE | Spinal Cord Ependymoma | — | 0.782 |
| 7 | 82992 | EPN | Supratentorial EPN | 0.778 |
| 8 | SRR8613716 | — | C | 0.765 |
| 9 | MBCProject_0381_T2_RNA | — | A | 0.765 |
| 10 | a4322796-9189-48c2-9e7c-7b1493b5799a | — | — | 0.756 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 36 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 0.555 | Remibrutinib | — uncovered |
| HYPOXIA | 0.406 | Idelalisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.390 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.370 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.359 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.342 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.329 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.311 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.300 | Idelalisib | — uncovered |
| MYOGENESIS | 0.293 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.285 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.280 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.278 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.267 | Remibrutinib | — uncovered |
| COAGULATION | 0.262 | Binimetinib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.234 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.228 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.197 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.188 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.187 | Inavolisib | — uncovered |