Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934865

2bfc71ad-6305-5a33-a7c7-c81f977a55f5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
36.793692509855454
age_years
39
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.549
  • TGF_BETA_SIGNALING+0.444
  • MYC_TARGETS_V2+0.377
  • MITOTIC_SPINDLE+0.369
  • INTERFERON_GAMMA_RESPONSE+0.362
  • G2M_CHECKPOINT+0.337
  • MYC_TARGETS_V1+0.334
  • NOTCH_SIGNALING+0.325
  • E2F_TARGETS+0.304
  • WNT_BETA_CATENIN_SIGNALING+0.273

Top 10 suppressed

  • SPERMATOGENESIS-0.340
  • KRAS_SIGNALING_DN-0.320
  • MYOGENESIS-0.287
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.244
  • ESTROGEN_RESPONSE_LATE-0.206
  • OXIDATIVE_PHOSPHORYLATION-0.193
  • PANCREAS_BETA_CELLS-0.187
  • COAGULATION-0.185
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.165
  • XENOBIOTIC_METABOLISM-0.140

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934808
brain-umap@2
0.931
2E35A6AA5-331F-489B-8CE1-9D0BC4CDE119
brain-umap@2
0.927
3C67163A8-8A5F-4398-AC65-167218B010CF
brain-umap@2
0.919
4EFB459E3-9B6A-4020-8556-6409065823B7
brain-umap@2
0.890
5SRR934763
brain-umap@2
0.885
615838786-D895-4F63-88A9-BDE627AE7958
brain-umap@2
0.882
7B2D8ED43-A698-4165-9A96-0ADEEFDA29ED
brain-umap@2
0.881
89EE765BF-748F-41B9-926F-FFD0E8C079E3
brain-umap@2
0.879
9SRR934780
brain-umap@2
0.879
10SRR934775
brain-umap@2
0.878

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.549Inavolisib— uncovered
TGF_BETA_SIGNALING0.444Inavolisib— uncovered
MYC_TARGETS_V20.377Idelalisib— uncovered
MITOTIC_SPINDLE0.369Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.362Idelalisib— uncovered
G2M_CHECKPOINT0.337Inavolisib— uncovered
MYC_TARGETS_V10.334Inavolisib— uncovered
NOTCH_SIGNALING0.325Inavolisib— uncovered
E2F_TARGETS0.304Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.273Inavolisib— uncovered
PROTEIN_SECRETION0.255Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.246Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.224Inavolisib— uncovered
ALLOGRAFT_REJECTION0.213Idelalisib— uncovered
DNA_REPAIR0.209Idelalisib— uncovered
HEDGEHOG_SIGNALING0.185Inavolisib— uncovered
ANDROGEN_RESPONSE0.147Inavolisib— uncovered
COMPLEMENT0.145Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.124Remibrutinib— uncovered
P53_PATHWAY0.108Idelalisib— uncovered