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TCGA-86-8279-01A-11R-2287-07

· cohortA1

2c589fa3-d2e5-5064-80aa-8e77363131d6

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
46

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-A7-A0D9-01A-31R-A056-07
breast-umap@18
B0.780
2SRR6013557
lung-landscapes@6
cohortA10.778
3TCGA-55-8087-01A-11R-2241-07
lung-landscapes@6
cohortA10.752
4TCGA-B6-A0I8-01A-11R-A034-07
breast-umap@18
B0.749
5SRR8613720
breast-umap@18
C0.748
6DRR168566
bladder-landscape@3
0.746
7SRR25617868
breast-umap@18
B0.729
8TCGA-C8-A3M8-01A-11R-A213-07
breast-umap@18
B0.728
9MDT-AP-1362
medullo-epn-umap@date-based
MedMedulloblastoma0.727
10MDT-AP-1357
medullo-epn-umap@date-based
MedMedulloblastoma0.725

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 12 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
DNA_REPAIR0.200Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.200Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.180Inavolisib— uncovered
MYOGENESIS0.170Inavolisib— uncovered
NOTCH_SIGNALING0.140Inavolisib— uncovered
ADIPOGENESIS0.110Inavolisib— uncovered
PEROXISOME0.110Idelalisib— uncovered
APICAL_JUNCTION0.100Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.080Remibrutinib— uncovered
TGF_BETA_SIGNALING0.070Inavolisib— uncovered
BILE_ACID_METABOLISM0.060Inavolisib— uncovered
PROTEIN_SECRETION0.050Remibrutinib— uncovered