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SRR6079981

2cf64f17-6522-5438-aa8a-91385ad6d997

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR650133
bladder-landscape@3
0.735
2TCGA-A7-A2KD-01A-31R-A21T-07
breast-umap@18
C0.711
3TCGA-62-8394-01A-11R-2326-07
lung-landscapes@6
cohortA10.646
4TCGA-BH-A0B5-01A-11R-A12P-07
breast-umap@18
A0.645
5SRR8526728
lung-landscapes@6
cohortSQ10.642
6s_150203_3a
medullo-epn-umap@date-based
EPNSupratentorial EPN0.641
7TCGA-CR-7368-01A-11R-2132-07
head-neck@1
0.636
8MDT-AP-1349
medullo-epn-umap@date-based
MedMedulloblastoma0.636
9X9a1a39b2.2a76.42cc.abba.cd82b2f5b3fe
lung-landscapes@6
cohortA10.631
10MNG255
mng-umap@100
0.627

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.390Inavolisib— uncovered
G2M_CHECKPOINT0.370Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.370Inavolisib— uncovered
MITOTIC_SPINDLE0.300Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.180Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.180Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.160Inavolisib— uncovered
UV_RESPONSE_DN0.160Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.150Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.150Inavolisib— uncovered
APICAL_SURFACE0.140Temsirolimus— uncovered
TGF_BETA_SIGNALING0.130Inavolisib— uncovered
HEDGEHOG_SIGNALING0.120Inavolisib— uncovered
APOPTOSIS0.090Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.090Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.020Idelalisib— uncovered
SPERMATOGENESIS0.020Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.010Inavolisib— uncovered