Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR12475155

2e92872d-92b7-5c20-b705-d35658978b88

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
145b4921e-fce7-41f8-bb63-ed98343ceec8
colon-landscapes@1
0.926
2SRR8392884
lung-landscapes@6
cohortA10.900
3C3L-02552
lung-landscapes@6
cohortSQ10.894
4SRR27320696
colon-landscapes@1
0.888
5TCGA-BH-A0BQ-01A-21R-A115-07
breast-umap@18
A0.880
6b65a6759-a9a4-4740-a9e3-962771dd9954
melanoma-umap@29
0.874
7SRR1341702
brain-umap@2
GTEX0.872
8BS_044XZ8ST
brain-umap@2
pilocytic astrocytoma0.866
9TCGA-BH-A0DV-01A-21R-A12P-07
breast-umap@18
A0.863
107c6f92ab-6cf8-4293-b676-2619c40f6ee6
colon-landscapes@1
0.863

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.410Inavolisib— uncovered
COAGULATION0.320Binimetinib— uncovered
MYOGENESIS0.310Inavolisib— uncovered
APICAL_JUNCTION0.300Inavolisib— uncovered
HEDGEHOG_SIGNALING0.300Inavolisib— uncovered
PANCREAS_BETA_CELLS0.290Cobimetinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.290Inavolisib— uncovered
HYPOXIA0.280Idelalisib— uncovered
APICAL_SURFACE0.270Temsirolimus— uncovered
NOTCH_SIGNALING0.270Inavolisib— uncovered
COMPLEMENT0.240Inavolisib— uncovered
ADIPOGENESIS0.220Inavolisib— uncovered
TGF_BETA_SIGNALING0.220Inavolisib— uncovered
ANGIOGENESIS0.210Remibrutinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.210Inavolisib— uncovered
IL2_STAT5_SIGNALING0.190Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.190Inavolisib— uncovered
P53_PATHWAY0.180Idelalisib— uncovered
ANDROGEN_RESPONSE0.160Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.150Remibrutinib— uncovered