C3L-02654
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 70.59000684
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.600
- INTERFERON_GAMMA_RESPONSE+0.430
- E2F_TARGETS+0.390
- MTORC1_SIGNALING+0.280
- G2M_CHECKPOINT+0.250
- INFLAMMATORY_RESPONSE+0.240
- SPERMATOGENESIS+0.200
- GLYCOLYSIS+0.190
- ALLOGRAFT_REJECTION+0.160
- IL6_JAK_STAT3_SIGNALING+0.140
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.440
- WNT_BETA_CATENIN_SIGNALING-0.430
- TGF_BETA_SIGNALING-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.390
- MYC_TARGETS_V2-0.360
- NOTCH_SIGNALING-0.320
- APICAL_JUNCTION-0.310
- HEDGEHOG_SIGNALING-0.310
- UV_RESPONSE_DN-0.270
- MYOGENESIS-0.240
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-55-A4DF-01A-11R-A24H-07 | — | cohortA3 | 0.821 |
| 2 | SRR650131 | — | — | 0.809 |
| 3 | SRR4195655 | — | — | 0.802 |
| 4 | TCGA-A8-A08I-01A-11R-A00Z-07 | — | C | 0.795 |
| 5 | SRR12202420 | — | — | 0.792 |
| 6 | SRR12475138 | — | — | 0.779 |
| 7 | SRR2016949 | — | — | 0.779 |
| 8 | s0122212 | — | — | 0.761 |
| 9 | 1f57edd1-3bc9-4eaf-8045-8984d5c7f148 | — | — | 0.740 |
| 10 | SRR12475116 | — | — | 0.738 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.600 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.430 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.390 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.280 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.250 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.240 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.190 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.160 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.140 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.140 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.140 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.130 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_UP | 0.120 | Inavolisib | — uncovered |