Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

SJEPD001513_D1.RNA-Seq

EPN · Posterior Fossa EPN

2f3b400f-728d-569f-8156-4c5ef26c9816

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
EPN
cancer_type_detailed
—
subtype
Posterior Fossa EPN
cancer_type
EPN
subtype
Posterior Fossa EPN
age_years
2
e1_e2
E1
umap1_2d
-4.538381594
umap2_2d
2.968360008
umap1_3d
-2.526477831
umap2_3d
2.605769062
umap3_3d
-1.510112678
dataset
EPN-StJude

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1EPT0673
medullo-epn-umap@date-based
EPNEPN Tumor0.881
2sclcWD9902_S47.txt
lung-landscapes@6
—cohortMD10.880
3MNG715
mng-umap@100
——0.868
4MNG541
mng-umap@100
——0.860
5BS_0HW7W7SD
brain-umap@2
Embryonal tumors—0.852
6TCGA-85-8664-01A-11R-2403-07
lung-landscapes@6
—cohortMD10.850
7MNG926
mng-umap@100
——0.838
8SRR8613740
breast-umap@18
—E0.838
9TCGA-D6-6823-01A-11R-1915-07
head-neck@1
——0.835
10BS_AM70R8RG
medullo-epn-umap@date-based
MedMedulloblastoma0.834

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.720Idelalisib— uncovered
MYC_TARGETS_V10.610Inavolisib— uncovered
E2F_TARGETS0.600Inavolisib— uncovered
G2M_CHECKPOINT0.600Inavolisib— uncovered
PANCREAS_BETA_CELLS0.460Cobimetinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.370Idelalisib— uncovered
APICAL_SURFACE0.340Temsirolimus— uncovered
MTORC1_SIGNALING0.330Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.290Inavolisib— uncovered
HEDGEHOG_SIGNALING0.210Inavolisib— uncovered
UV_RESPONSE_UP0.200Idelalisib— uncovered
MITOTIC_SPINDLE0.190Inavolisib— uncovered
SPERMATOGENESIS0.180Inavolisib— uncovered
ANGIOGENESIS0.170Remibrutinib— uncovered
KRAS_SIGNALING_DN0.130Remibrutinib— uncovered
DNA_REPAIR0.120Idelalisib— uncovered
GLYCOLYSIS0.100Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.090Idelalisib— uncovered
TGF_BETA_SIGNALING0.070Inavolisib— uncovered
NOTCH_SIGNALING0.040Inavolisib— uncovered