Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-XF-A9T0-01A-11R-A39I-07

2fbfc529-5f0f-5a1d-946b-b07696a81cc8

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
26.24835742
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.540
  • UNFOLDED_PROTEIN_RESPONSE+0.380
  • MYC_TARGETS_V1+0.360
  • DNA_REPAIR+0.340
  • OXIDATIVE_PHOSPHORYLATION+0.260
  • ANGIOGENESIS+0.240
  • E2F_TARGETS+0.210
  • MTORC1_SIGNALING+0.210
  • PROTEIN_SECRETION+0.190
  • ADIPOGENESIS+0.110

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.700
  • INTERFERON_GAMMA_RESPONSE-0.510
  • TNFA_SIGNALING_VIA_NFKB-0.320
  • COMPLEMENT-0.310
  • INFLAMMATORY_RESPONSE-0.300
  • KRAS_SIGNALING_DN-0.280
  • ESTROGEN_RESPONSE_LATE-0.260
  • COAGULATION-0.250
  • HEDGEHOG_SIGNALING-0.250
  • IL6_JAK_STAT3_SIGNALING-0.250

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3N-03076
lung-landscapes@6
cohortMD10.843
2X0c9d8dde.aec7.4a95.b86c.da554465897b
lung-landscapes@6
cohortSQ10.833
3MNG332
mng-umap@100
0.831
4SRR8518345
breast-umap@18
E0.831
59ca1da07-df79-4bbf-be81-0ef9de95ab0c
melanoma-umap@29
0.828
6ERR2278885
head-neck@1
0.824
7C3N-02290
lung-landscapes@6
cohortA40.821
8SRR6013505
lung-landscapes@6
cohortA40.820
9176e93be-1ae5-43f2-a0b5-17f31695e679
melanoma-umap@29
0.820
10TCGA-UF-A71A-06A-11R-A39I-07
head-neck@1
0.817

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 14 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.540Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.380Idelalisib— uncovered
MYC_TARGETS_V10.360Inavolisib— uncovered
DNA_REPAIR0.340Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.260Remibrutinib— uncovered
ANGIOGENESIS0.240Remibrutinib— uncovered
E2F_TARGETS0.210Inavolisib— uncovered
MTORC1_SIGNALING0.210Inavolisib— uncovered
PROTEIN_SECRETION0.190Remibrutinib— uncovered
ADIPOGENESIS0.110Inavolisib— uncovered
G2M_CHECKPOINT0.110Inavolisib— uncovered
HYPOXIA0.100Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.030Inavolisib— uncovered
GLYCOLYSIS0.030Inavolisib— uncovered