Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-B6-A1KI-01A-11R-A14M-07

· B

337fc05d-a640-56be-9300-dccc247b1651

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
75

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • NOTCH_SIGNALING+0.430
  • HEDGEHOG_SIGNALING+0.400
  • BILE_ACID_METABOLISM+0.350
  • FATTY_ACID_METABOLISM+0.310
  • ESTROGEN_RESPONSE_EARLY+0.300
  • PROTEIN_SECRETION+0.280
  • UV_RESPONSE_DN+0.280
  • TGF_BETA_SIGNALING+0.270
  • ANGIOGENESIS+0.260
  • MYOGENESIS+0.260

Top 10 suppressed

  • E2F_TARGETS-0.600
  • G2M_CHECKPOINT-0.570
  • ALLOGRAFT_REJECTION-0.520
  • INTERFERON_GAMMA_RESPONSE-0.490
  • MYC_TARGETS_V1-0.480
  • INTERFERON_ALPHA_RESPONSE-0.470
  • MYC_TARGETS_V2-0.450
  • INFLAMMATORY_RESPONSE-0.360
  • TNFA_SIGNALING_VIA_NFKB-0.330
  • SPERMATOGENESIS-0.270

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8613754
breast-umap@18
F0.884
2TCGA-AN-A0FS-01A-11R-A034-07
breast-umap@18
A0.852
3SRR8518290
breast-umap@18
F0.850
4TCGA-62-8395-01A-11R-2326-07
lung-landscapes@6
cohortA20.844
5C3N-01021
lung-landscapes@6
cohortA10.839
6TCGA-D8-A27P-01A-11R-A16F-07
breast-umap@18
B0.836
7TCGA-CN-4722-01A-01R-1436-07
head-neck@1
0.831
8TCGA-AC-A2FG-01A-11R-A17B-07
breast-umap@18
A0.831
920030071.Her2HRpos
breast-umap@18
A0.827
10TCGA-73-4675-01A-01R-1206-07
lung-landscapes@6
cohortA20.820

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 21 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
NOTCH_SIGNALING0.430Inavolisib— uncovered
HEDGEHOG_SIGNALING0.400Inavolisib— uncovered
BILE_ACID_METABOLISM0.350Inavolisib— uncovered
FATTY_ACID_METABOLISM0.310Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.300Inavolisib— uncovered
PROTEIN_SECRETION0.280Remibrutinib— uncovered
UV_RESPONSE_DN0.280Inavolisib— uncovered
TGF_BETA_SIGNALING0.270Inavolisib— uncovered
ANGIOGENESIS0.260Remibrutinib— uncovered
MYOGENESIS0.260Inavolisib— uncovered
ADIPOGENESIS0.250Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.250Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.240Remibrutinib— uncovered
ANDROGEN_RESPONSE0.190Inavolisib— uncovered
APICAL_SURFACE0.180Temsirolimus— uncovered
HEME_METABOLISM0.180Temsirolimus— uncovered
WNT_BETA_CATENIN_SIGNALING0.150Inavolisib— uncovered
PEROXISOME0.130Idelalisib— uncovered
COAGULATION0.110Binimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.110Inavolisib— uncovered