Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-ZF-A9RL-01A-11R-A38B-07

356224ae-fd53-5052-b8af-08cddf8ff94f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
88.79763469
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • BILE_ACID_METABOLISM+0.210
  • ANDROGEN_RESPONSE+0.170
  • PEROXISOME+0.170
  • G2M_CHECKPOINT+0.140
  • SPERMATOGENESIS+0.120
  • PROTEIN_SECRETION+0.110
  • FATTY_ACID_METABOLISM+0.080
  • TGF_BETA_SIGNALING+0.080
  • MTORC1_SIGNALING+0.050
  • XENOBIOTIC_METABOLISM+0.010

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.630
  • ALLOGRAFT_REJECTION-0.550
  • INFLAMMATORY_RESPONSE-0.530
  • INTERFERON_ALPHA_RESPONSE-0.520
  • ANGIOGENESIS-0.510
  • INTERFERON_GAMMA_RESPONSE-0.500
  • TNFA_SIGNALING_VIA_NFKB-0.500
  • IL6_JAK_STAT3_SIGNALING-0.470
  • APICAL_JUNCTION-0.440
  • COMPLEMENT-0.390

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-DK-AA76-01A-11R-A39I-07
bladder-landscape@3
0.930
2TCGA-GV-A3JW-01A-11R-A20F-07
bladder-landscape@3
0.921
3DRR168589
bladder-landscape@3
0.890
4SRR8943016
bladder-landscape@3
0.889
5TCGA-CN-6988-01A-11R-1915-07
head-neck@1
0.888
6TCGA-GU-A42P-01A-11R-A23W-07
bladder-landscape@3
0.885
7TCGA-G2-A3VY-01A-11R-A22U-07
bladder-landscape@3
0.880
8TCGA-A7-A0DC-01A-11R-A00Z-07
breast-umap@18
D0.879
9TCGA-FJ-A3ZE-01A-11R-A23N-07
bladder-landscape@3
0.874
10SRR8943037
bladder-landscape@3
0.863

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
BILE_ACID_METABOLISM0.210Inavolisib— uncovered
ANDROGEN_RESPONSE0.170Inavolisib— uncovered
PEROXISOME0.170Idelalisib— uncovered
G2M_CHECKPOINT0.140Inavolisib— uncovered
SPERMATOGENESIS0.120Inavolisib— uncovered
PROTEIN_SECRETION0.110Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.080Inavolisib— uncovered
TGF_BETA_SIGNALING0.080Inavolisib— uncovered
MTORC1_SIGNALING0.050Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.010Inavolisib— uncovered