Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-44-6779-01A-11R-1858-07

· cohortA1

35aad824-6643-59df-b44c-82b506001494

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
50

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_0SCXXM6N
brain-umap@2
low-grade glioma0.908
2TCGA-49-6745-01A-11R-1858-07
lung-landscapes@6
cohortA10.885
3957a7228-3558-48fd-81d9-13f951e0b597
melanoma-umap@29
0.885
4c55bb20b-c929-42e2-be7f-8b1da7bee953
melanoma-umap@29
0.883
5BS_VP5Y45Z7
brain-umap@2
pilocytic astrocytoma0.883
6SRR934980
brain-umap@2
0.875
7TCGA-DK-A2I4-01A-11R-A21D-07
bladder-landscape@3
0.872
8TCGA-AN-A0XW-01A-11R-A109-07
breast-umap@18
C0.872
9TCGA-CR-7395-01A-11R-2016-07
head-neck@1
0.867
10MDT-AP-2029
medullo-epn-umap@date-based
MedMedulloblastoma0.867

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.600Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.600Idelalisib— uncovered
ALLOGRAFT_REJECTION0.530Idelalisib— uncovered
COMPLEMENT0.480Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.480Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.460Inavolisib— uncovered
MITOTIC_SPINDLE0.410Inavolisib— uncovered
PROTEIN_SECRETION0.400Remibrutinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.400Inavolisib— uncovered
APICAL_JUNCTION0.370Inavolisib— uncovered
APOPTOSIS0.370Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.370Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.370Inavolisib— uncovered
APICAL_SURFACE0.360Temsirolimus— uncovered
ANDROGEN_RESPONSE0.350Inavolisib— uncovered
ANGIOGENESIS0.350Remibrutinib— uncovered
KRAS_SIGNALING_UP0.350Inavolisib— uncovered
TGF_BETA_SIGNALING0.350Inavolisib— uncovered
UV_RESPONSE_DN0.340Inavolisib— uncovered
G2M_CHECKPOINT0.320Inavolisib— uncovered