Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-UY-A9PB-01A-11R-A38B-07

36277ebe-22e1-5f38-9cd9-5c199c621d0e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
29.53350854
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.670
  • INTERFERON_GAMMA_RESPONSE+0.600
  • ALLOGRAFT_REJECTION+0.530
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.490
  • COMPLEMENT+0.460
  • DNA_REPAIR+0.440
  • INFLAMMATORY_RESPONSE+0.430
  • TNFA_SIGNALING_VIA_NFKB+0.430
  • IL6_JAK_STAT3_SIGNALING+0.410
  • MYC_TARGETS_V1+0.410

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.350
  • SPERMATOGENESIS-0.310
  • PANCREAS_BETA_CELLS-0.270
  • BILE_ACID_METABOLISM-0.200
  • PEROXISOME-0.180
  • ESTROGEN_RESPONSE_EARLY-0.140
  • ESTROGEN_RESPONSE_LATE-0.080
  • ADIPOGENESIS-0.070
  • FATTY_ACID_METABOLISM-0.070
  • MYOGENESIS-0.050

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1A678E1E5-E02D-49A1-BB2B-C91A60E6382E
brain-umap@2
0.941
2SRR934722
brain-umap@2
0.941
3SRR934864
brain-umap@2
0.940
4TCGA-4Z-AA86-01A-11R-A39I-07
bladder-landscape@3
0.939
5TCGA-XF-A9SM-01A-11R-A42T-07
bladder-landscape@3
0.937
6TCGA-XF-A9SY-01A-21R-A42T-07
bladder-landscape@3
0.937
762966348-1C16-4A6D-AA82-707B3F759D5C
brain-umap@2
0.936
8795FBB8C-0E74-477F-AA27-1CE97A4E90B9
brain-umap@2
0.933
9SRR934874
brain-umap@2
0.925
10AF0A7BAA-D031-4C9F-91B7-7034F2C49D72
brain-umap@2
0.924

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.670Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.600Idelalisib— uncovered
ALLOGRAFT_REJECTION0.530Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.490Inavolisib— uncovered
COMPLEMENT0.460Inavolisib— uncovered
DNA_REPAIR0.440Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.430Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.430Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.410Inavolisib— uncovered
MYC_TARGETS_V10.410Inavolisib— uncovered
MYC_TARGETS_V20.410Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.410Idelalisib— uncovered
COAGULATION0.400Binimetinib— uncovered
APOPTOSIS0.380Idelalisib— uncovered
E2F_TARGETS0.360Inavolisib— uncovered
IL2_STAT5_SIGNALING0.320Idelalisib— uncovered
MITOTIC_SPINDLE0.320Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.320Inavolisib— uncovered
ANGIOGENESIS0.300Remibrutinib— uncovered
TGF_BETA_SIGNALING0.300Inavolisib— uncovered