Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-ZF-A9RD-01A-11R-A42T-07

374f24e8-f222-5e79-9f7a-046553e6e3af

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
13.40341656
os_event
true
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-22-0940-01A-01R-0692-07
lung-landscapes@6
cohortSQ10.933
2TCGA-66-2765-01A-01R-0851-07
lung-landscapes@6
cohortSQ10.931
3TCGA-FD-A6TD-01A-51R-A33J-07
bladder-landscape@3
0.920
4AE47BCDE-A2D2-43EF-8EC7-78E4D1817EEE
brain-umap@2
0.918
55063882F-6377-4976-BB48-7275D46C44E6
brain-umap@2
0.913
6TCGA-33-4566-01A-01R-1443-07
lung-landscapes@6
cohortA10.912
7TCGA-DK-A3WW-01A-22R-A23N-07
bladder-landscape@3
0.910
8MNG256
mng-umap@100
0.908
9TCGA-FD-A5C1-01A-11R-A28M-07
bladder-landscape@3
0.907
10D06FFD0C-80D4-413D-9C83-62D9C163EDAB
brain-umap@2
0.906

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 43 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.600Inavolisib— uncovered
ALLOGRAFT_REJECTION0.590Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.580Idelalisib— uncovered
MYC_TARGETS_V10.520Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.520Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.510Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.500Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.470Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.460Remibrutinib— uncovered
E2F_TARGETS0.440Inavolisib— uncovered
COMPLEMENT0.430Inavolisib— uncovered
MTORC1_SIGNALING0.410Inavolisib— uncovered
G2M_CHECKPOINT0.400Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.340Inavolisib— uncovered
IL2_STAT5_SIGNALING0.330Idelalisib— uncovered
MYC_TARGETS_V20.330Idelalisib— uncovered
P53_PATHWAY0.320Idelalisib— uncovered
APOPTOSIS0.310Idelalisib— uncovered
DNA_REPAIR0.310Idelalisib— uncovered
GLYCOLYSIS0.290Inavolisib— uncovered