SRR1417047
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.361
- SPERMATOGENESIS+0.275
- PANCREAS_BETA_CELLS+0.214
- HEDGEHOG_SIGNALING+0.200
- APICAL_JUNCTION+0.074
- OXIDATIVE_PHOSPHORYLATION+0.047
- MYOGENESIS+0.040
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.001
- APICAL_SURFACE-0.015
- UV_RESPONSE_UP-0.046
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.588
- IL6_JAK_STAT3_SIGNALING-0.551
- INTERFERON_GAMMA_RESPONSE-0.540
- TNFA_SIGNALING_VIA_NFKB-0.427
- E2F_TARGETS-0.419
- MYC_TARGETS_V1-0.404
- TGF_BETA_SIGNALING-0.403
- ANGIOGENESIS-0.383
- INFLAMMATORY_RESPONSE-0.374
- MTORC1_SIGNALING-0.372
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1335400 | GTEX | — | 0.976 |
| 2 | SRR1459441 | GTEX | — | 0.974 |
| 3 | SRR614310 | GTEX | — | 0.974 |
| 4 | SRR1333741 | GTEX | — | 0.972 |
| 5 | SRR1490019 | GTEX | — | 0.970 |
| 6 | SRR660933 | GTEX | — | 0.970 |
| 7 | SRR1433971 | GTEX | — | 0.969 |
| 8 | SRR1470175 | GTEX | — | 0.968 |
| 9 | SRR1320093 | GTEX | — | 0.967 |
| 10 | SRR660626 | GTEX | — | 0.965 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.361 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.275 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.214 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.200 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.074 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.047 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.040 | Inavolisib | — uncovered |