SRR1313426
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1325927 | GTEX | — | 0.950 |
| 2 | SJEPD001533_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.942 |
| 3 | SRR1429725 | GTEX | — | 0.941 |
| 4 | MDT-AP-1142 | Med | Medulloblastoma | 0.940 |
| 5 | SRR1468974 | GTEX | — | 0.939 |
| 6 | SJEPD001523_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.937 |
| 7 | SRR1500617 | GTEX | — | 0.935 |
| 8 | SRR1340301 | GTEX | — | 0.931 |
| 9 | SRR1389348 | GTEX | — | 0.930 |
| 10 | SRR1458810 | GTEX | — | 0.929 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 18 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.461 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.349 | Cobimetinib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.277 | Idelalisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.274 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.240 | Inavolisib | — uncovered |
| COAGULATION | 0.234 | Binimetinib | — uncovered |
| MYOGENESIS | 0.212 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.206 | Temsirolimus | — uncovered |
| SPERMATOGENESIS | 0.157 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.143 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.103 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.102 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.022 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.015 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.014 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.007 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.005 | Idelalisib | — uncovered |
| ANGIOGENESIS | 0.003 | Remibrutinib | — uncovered |