Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · melanoma-umap@29

43c87798-5762-42c1-b7d8-47fc126fc2d3

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38ac6b48-9d2d-50bd-b4d2-5ea2f81b6e93

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-E2-A574-01A-11R-A29R-07
breast-umap@18
—E0.879
2MDT-AP-2286
medullo-epn-umap@date-based
MedMedulloblastoma0.875
3TCGA-39-5037-01A-01R-1443-07
lung-landscapes@6
—cohortSQ20.864
4SRR5088864
melanoma-umap@29
——0.863
5TCGA-64-1678-01A-01R-0946-07
lung-landscapes@6
—cohortA30.860
6R309
bladder-landscape@3
——0.842
7MDT-AP-0412
medullo-epn-umap@date-based
MedMedulloblastoma0.839
8TCGA-YC-A9TC-01A-22R-A39I-07
bladder-landscape@3
——0.839
9TCGA-AC-A62V-01A-11R-A31O-07
breast-umap@18
—B0.834
10TCGA-66-2781-01A-01R-0851-07
lung-landscapes@6
—cohortSQ20.826

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.600Idelalisib— uncovered
MYC_TARGETS_V10.500Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.400Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.400Cobimetinib— uncovered
E2F_TARGETS0.300Inavolisib— uncovered
MTORC1_SIGNALING0.300Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.200Remibrutinib— uncovered
DNA_REPAIR0.200Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.200Idelalisib— uncovered
G2M_CHECKPOINT0.200Inavolisib— uncovered
SPERMATOGENESIS0.200Inavolisib— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
ANGIOGENESIS0.100Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.100Inavolisib— uncovered
FATTY_ACID_METABOLISM0.100Inavolisib— uncovered
GLYCOLYSIS0.100Inavolisib— uncovered
KRAS_SIGNALING_DN0.100Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.100Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.100Idelalisib— uncovered
UV_RESPONSE_UP0.100Idelalisib— uncovered