Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

ERR2598197

fetal · fetal

3b0e395a-7e2c-5669-b35c-c781ec080be5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
—
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_hindbrain
6
umap1_2d
-2.401182907
umap2_2d
-0.76134791
umap1_3d
-3.723804962
umap2_3d
3.257938533
umap3_3d
-1.694065184
dataset
fetal

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • E2F_TARGETS+0.650
  • G2M_CHECKPOINT+0.630
  • MYC_TARGETS_V1+0.550
  • WNT_BETA_CATENIN_SIGNALING+0.500
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.490
  • TGF_BETA_SIGNALING+0.470
  • MITOTIC_SPINDLE+0.430
  • ANDROGEN_RESPONSE+0.410
  • UNFOLDED_PROTEIN_RESPONSE+0.390
  • MYC_TARGETS_V2+0.370

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.320
  • OXIDATIVE_PHOSPHORYLATION-0.280
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.270
  • ALLOGRAFT_REJECTION-0.230
  • INTERFERON_GAMMA_RESPONSE-0.210
  • COMPLEMENT-0.180
  • INFLAMMATORY_RESPONSE-0.130
  • IL6_JAK_STAT3_SIGNALING-0.120
  • XENOBIOTIC_METABOLISM-0.120
  • UV_RESPONSE_UP-0.090

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2598184
medullo-epn-umap@date-based
fetalfetal0.949
2ERR2598180
medullo-epn-umap@date-based
fetalfetal0.903
3ERR2598170
medullo-epn-umap@date-based
fetalfetal0.895
4ERR2598171
medullo-epn-umap@date-based
fetalfetal0.893
5TCGA-60-2703-01A-11R-2045-07
lung-landscapes@6
—cohortSQ10.878
6ERR2598185
medullo-epn-umap@date-based
fetalfetal0.876
7ERR2598166
medullo-epn-umap@date-based
fetalfetal0.876
8ERR2598169
medullo-epn-umap@date-based
fetalfetal0.874
9ERR2598181
medullo-epn-umap@date-based
fetalfetal0.871
10ERR2598207
medullo-epn-umap@date-based
fetalfetal0.850

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.650Inavolisib— uncovered
G2M_CHECKPOINT0.630Inavolisib— uncovered
MYC_TARGETS_V10.550Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.500Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.490Inavolisib— uncovered
TGF_BETA_SIGNALING0.470Inavolisib— uncovered
MITOTIC_SPINDLE0.430Inavolisib— uncovered
ANDROGEN_RESPONSE0.410Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.390Idelalisib— uncovered
MYC_TARGETS_V20.370Idelalisib— uncovered
MTORC1_SIGNALING0.360Inavolisib— uncovered
NOTCH_SIGNALING0.360Inavolisib— uncovered
ANGIOGENESIS0.320Remibrutinib— uncovered
PROTEIN_SECRETION0.320Remibrutinib— uncovered
GLYCOLYSIS0.280Inavolisib— uncovered
UV_RESPONSE_DN0.280Inavolisib— uncovered
DNA_REPAIR0.240Idelalisib— uncovered
HYPOXIA0.240Idelalisib— uncovered
HEME_METABOLISM0.230Temsirolimus— uncovered
PANCREAS_BETA_CELLS0.160Cobimetinib— uncovered