8ca13509-abad-46b7-92f4-fa741bc52b42
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 69
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.410
- E2F_TARGETS+0.400
- MITOTIC_SPINDLE+0.370
- PROTEIN_SECRETION+0.360
- SPERMATOGENESIS+0.290
- ANDROGEN_RESPONSE+0.260
- BILE_ACID_METABOLISM+0.240
- PI3K_AKT_MTOR_SIGNALING+0.150
- OXIDATIVE_PHOSPHORYLATION+0.130
- MTORC1_SIGNALING+0.110
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.490
- ANGIOGENESIS-0.450
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.440
- ALLOGRAFT_REJECTION-0.430
- COAGULATION-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- IL6_JAK_STAT3_SIGNALING-0.380
- COMPLEMENT-0.340
- MYOGENESIS-0.340
- WNT_BETA_CATENIN_SIGNALING-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | e7f9aa2a-9c1b-4c63-953b-4922fafd9150 | — | — | 0.913 |
| 2 | MDT-AP-3021 | Med | Medulloblastoma | 0.901 |
| 3 | SJEPD031592_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.888 |
| 4 | TCGA-E9-A1R7-01A-11R-A14M-07 | — | B | 0.885 |
| 5 | SRR12202425 | — | — | 0.882 |
| 6 | R360 | — | — | 0.876 |
| 7 | SRR2167642 | GTEX | — | 0.876 |
| 8 | R6 | — | — | 0.875 |
| 9 | MDT-AP-0188 | Med | Medulloblastoma | 0.870 |
| 10 | 2c343b93-910c-4921-bc2b-f7fbfa4f1596 | — | — | 0.865 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.410 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.400 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.370 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.360 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.290 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.260 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.240 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.150 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.130 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.110 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.080 | Idelalisib | — uncovered |
| PEROXISOME | 0.070 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.030 | Inavolisib | — uncovered |