Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BSR_19_0096_S47

· A

3cafd6e9-ad06-5765-ad01-acf3dd502bdc

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.450
  • ESTROGEN_RESPONSE_EARLY+0.440
  • IL2_STAT5_SIGNALING+0.420
  • TNFA_SIGNALING_VIA_NFKB+0.410
  • ALLOGRAFT_REJECTION+0.390
  • ESTROGEN_RESPONSE_LATE+0.380
  • COMPLEMENT+0.370
  • IL6_JAK_STAT3_SIGNALING+0.360
  • ANGIOGENESIS+0.350
  • ADIPOGENESIS+0.330

Top 10 suppressed

  • MYC_TARGETS_V2-0.300
  • PANCREAS_BETA_CELLS-0.210
  • MYC_TARGETS_V1-0.200
  • SPERMATOGENESIS-0.120
  • PROTEIN_SECRETION-0.110
  • DNA_REPAIR-0.100
  • UNFOLDED_PROTEIN_RESPONSE-0.100
  • OXIDATIVE_PHOSPHORYLATION-0.070
  • G2M_CHECKPOINT-0.060
  • INTERFERON_ALPHA_RESPONSE-0.040

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1718de66e-06d2-4c2c-8b2d-e40087c4340c
melanoma-umap@29
0.848
2BS_593HEWBF
brain-umap@2
Ganglioglioma0.848
3EPT0509
medullo-epn-umap@date-based
EPNEPN Tumor0.848
4TCGA-60-2707-01A-01R-0851-07
lung-landscapes@6
cohortSQ10.839
5SRR10900576
melanoma-umap@29
0.836
6BS_HC5M8JTC
brain-umap@2
low-grade glioma0.831
7SRR1331597
brain-umap@2
GTEX0.830
8SRR33346953
bladder-landscape@3
0.830
9TCGA-64-5815-01A-01R-1628-07
lung-landscapes@6
cohortA10.829
10BS_S7CZY2CH
brain-umap@2
low-grade glioma0.828

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 37 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.450Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.440Inavolisib— uncovered
IL2_STAT5_SIGNALING0.420Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.410Inavolisib— uncovered
ALLOGRAFT_REJECTION0.390Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.380Idelalisib— uncovered
COMPLEMENT0.370Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.360Inavolisib— uncovered
ANGIOGENESIS0.350Remibrutinib— uncovered
ADIPOGENESIS0.330Inavolisib— uncovered
FATTY_ACID_METABOLISM0.330Inavolisib— uncovered
UV_RESPONSE_DN0.330Inavolisib— uncovered
APOPTOSIS0.320Idelalisib— uncovered
KRAS_SIGNALING_UP0.320Inavolisib— uncovered
HEDGEHOG_SIGNALING0.310Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.310Idelalisib— uncovered
MYOGENESIS0.300Inavolisib— uncovered
ANDROGEN_RESPONSE0.280Inavolisib— uncovered
COAGULATION0.270Binimetinib— uncovered
HYPOXIA0.270Idelalisib— uncovered