Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-78-7167-01A-11R-2066-07

· cohortA2

3cf5ab9e-2a16-51e4-804a-a97e6a77a0a0

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA2
subtype
cohortA2
age_years
77

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • FATTY_ACID_METABOLISM+0.280
  • WNT_BETA_CATENIN_SIGNALING+0.260
  • TGF_BETA_SIGNALING+0.200
  • ADIPOGENESIS+0.160
  • PEROXISOME+0.150
  • PROTEIN_SECRETION+0.110
  • HEME_METABOLISM+0.090
  • NOTCH_SIGNALING+0.070
  • UV_RESPONSE_DN+0.070
  • OXIDATIVE_PHOSPHORYLATION+0.030

Top 10 suppressed

  • E2F_TARGETS-0.610
  • INTERFERON_GAMMA_RESPONSE-0.560
  • G2M_CHECKPOINT-0.550
  • INFLAMMATORY_RESPONSE-0.550
  • IL6_JAK_STAT3_SIGNALING-0.530
  • ALLOGRAFT_REJECTION-0.520
  • INTERFERON_ALPHA_RESPONSE-0.520
  • TNFA_SIGNALING_VIA_NFKB-0.510
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.430
  • MTORC1_SIGNALING-0.420

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-MP-A5C7-01A-11R-A262-07
lung-landscapes@6
cohortA20.932
2TCGA-78-7156-01A-11R-2039-07
lung-landscapes@6
cohortA20.915
3C3N-02973
lung-landscapes@6
cohortA10.908
4TCGA-55-8087-01A-11R-2241-07
lung-landscapes@6
cohortA10.892
5C3L-03721
lung-landscapes@6
cohortA20.887
6SRR8943006
bladder-landscape@3
0.875
7SRR1516058
bladder-landscape@3
0.871
8TCGA-A2-A4S0-01A-21R-A266-07
breast-umap@18
B0.868
9C3L-03726
lung-landscapes@6
cohortA20.867
10ERR2278853
head-neck@1
0.858

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
FATTY_ACID_METABOLISM0.280Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.260Inavolisib— uncovered
TGF_BETA_SIGNALING0.200Inavolisib— uncovered
ADIPOGENESIS0.160Inavolisib— uncovered
PEROXISOME0.150Idelalisib— uncovered
PROTEIN_SECRETION0.110Remibrutinib— uncovered
HEME_METABOLISM0.090Temsirolimus— uncovered
NOTCH_SIGNALING0.070Inavolisib— uncovered
UV_RESPONSE_DN0.070Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.030Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.030Cobimetinib— uncovered
BILE_ACID_METABOLISM0.010Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.010Inavolisib— uncovered